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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Blood pressure dynamics during pregnancy and spontaneous preterm birth
American Journal of Obstetrics and Gynecology, Volume 197, No. 2, Year 2007
Notification
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Description
Objective: The objective of the study was to examine whether blood pressure in early pregnancy and its rise in the second half of gestation are associated with spontaneous preterm birth in healthy, normotensive, nulliparous women. Study Design: We included 5167 women with singleton gestation who participated in the World Health Organization Calcium Supplementation for the Prevention of Preeclampsia Trial. Systolic, diastolic, and mean arterial blood pressure and pulse pressure at baseline (12-19 weeks of gestation) and at the midthird trimester (30-34 weeks) were calculated. Rise in blood pressure was the difference between the midthird trimester and baseline. Preterm birth was defined as early preterm (less than 34 completed weeks) and late preterm birth (34-36 weeks). Results: Women experiencing early or late preterm birth had over 10 mm Hg and 3 mm Hg higher rise, respectively, in systolic, diastolic, and mean arterial blood pressure than women delivering at term. A rise in systolic pressure over 30 mm Hg or diastolic pressure over 15 mm Hg was associated with a statistically significant 2- to 3-fold increase in risk of spontaneous preterm birth. Conclusion: An excessive rise in either systolic or diastolic blood pressures from early pregnancy to the midthird trimester is associated with spontaneous preterm birth in a dose-response pattern. © 2007 Mosby, Inc. All rights reserved.
Authors & Co-Authors
Zhang, Jun
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Villar, Josè
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Sun, Wenyu
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Merialdi, Mario
Switzerland, Geneva
Organisation Mondiale de la Santé
Abdel-Aleem, Hany
Egypt, Asyut
Assiut University
Mathai, Matthews
India, Vellore
Christian Medical College, Vellore
Ali, Mohamed Mahmoud
Switzerland, Geneva
Organisation Mondiale de la Santé
Yu, Kai Fun
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Zavaleta, Nelly M.
Peru, Lima
Instituto de Investigacion Nutricional
Purwar, Manorama B.
India, Nagpur
Government Medical College Nagpur
Nhu Ngoc, Nguyen Thi
Viet Nam, Ho Chi Minh City
Hung Vuong Hospital
Campódonico, Liana
Argentina, Rosario
Centro Rosarino de Estudios Perinatales
Landoulsi, Sihem Bent
Switzerland, Geneva
Organisation Mondiale de la Santé
Lindheimer, Marshall D.
United States, Chicago
Pritzker School of Medicine
Carroli, Guillermo
Argentina, Rosario
Centro Rosarino de Estudios Perinatales
Statistics
Citations: 70
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1016/j.ajog.2007.03.053
ISSN:
00029378
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Participants Gender
Female