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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Progression of White Matter Disease and Cortical Thinning Are Not Related in Older Community-Dwelling Subjects
Stroke, Volume 47, No. 2, Year 2016
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Description
Background and Purpose-We assessed cross-sectional and longitudinal relationships between whole brain white matter hyperintensity (WMH) volume and regional cortical thickness. Methods-We measured WMH volume and regional cortical thickness on magnetic resonance imaging at ≈73 and ≈76 years in 351 community-dwelling subjects from the Lothian Birth Cohort 1936. We used multiple linear regression to calculate cross-sectional and longitudinal associations between regional cortical thickness and WMH volume controlling for age, sex, Mini Mental State Examination, education, intelligence quotient at age 11, and vascular risk factors. Results-We found cross-sectional associations between WMH volume and cortical thickness within and surrounding the Sylvian fissure at 73 and 76 years (rho=-0.276, Q=0.004). However, we found no significant longitudinal associations between (1) baseline WMH volume and change in cortical thickness; (2) baseline cortical thickness and change in WMH volume; or (3) change in WMH volume and change in cortical thickness. Conclusions-Our results show that WMH volume and cortical thinning both worsen with age and are associated cross-sectionally within and surrounding the Sylvian fissure. However, changes in WMH volume and cortical thinning from 73 to 76 years are not associated longitudinally in these relatively healthy older subjects. The underlying cause(s) of WMH growth and cortical thinning have yet to be fully determined. © 2016 American Heart Association, Inc.
Authors & Co-Authors
Dickie, David Alexander
United Kingdom, Edinburgh
The University of Edinburgh
Karama, Sherif
Canada, Montreal
Université Mcgill
Ritchie, Stuart J.
United Kingdom, Edinburgh
The University of Edinburgh
Cox, Simon R.
United Kingdom, Edinburgh
The University of Edinburgh
Royle, Natalie A.
United Kingdom, Edinburgh
The University of Edinburgh
Aribisala, Benjamin Segun
United Kingdom, Edinburgh
The University of Edinburgh
Hernández, Maria Valdés
United Kingdom, Edinburgh
The University of Edinburgh
Muñoz Maniega, Susana
United Kingdom, Edinburgh
The University of Edinburgh
Pattie, Alison
United Kingdom, Edinburgh
The University of Edinburgh
Corley, Janie
United Kingdom, Edinburgh
The University of Edinburgh
Starr, John M.
United Kingdom, Edinburgh
The University of Edinburgh
Bastin, Mark E.
United Kingdom, Edinburgh
The University of Edinburgh
Collins, Donald Louis
Canada, Montreal
Université Mcgill
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 30
Authors: 15
Affiliations: 2
Identifiers
Doi:
10.1161/STROKEAHA.115.011229
ISSN:
00392499
Study Design
Cross Sectional Study
Cohort Study