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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Symptoms and transmission of SARS-CoV-2 among children - Utah and Wisconsin, March-May 2020
Pediatrics, Volume 147, No. 1, Article e2020027268, Year 2021
Notification
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Description
BACKGROUND AND OBJECTIVES: Limited data exist on severe acute respiratory syndrome coronavirus 2 in children. We described infection rates and symptom profiles among pediatric household contacts of individuals with coronavirus disease 2019. METHODS: We enrolled individuals with coronavirus disease 2019 and their household contacts, assessed daily symptoms prospectively for 14 days, and obtained specimens for severe acute respiratory syndrome coronavirus 2 real-time reverse transcription polymerase chain reaction and serology testing. Among pediatric contacts (,18 years), we described transmission, assessed the risk factors for infection, and calculated symptom positive and negative predictive values. We compared secondary infection rates and symptoms between pediatric and adult contacts using generalized estimating equations. RESULTS: Among 58 households, 188 contacts were enrolled (120 adults; 68 children). Secondary infection rates for adults (30%) and children (28%) were similar. Among households with potential for transmission from children, child-to-adult transmission may have occurred in 2 of 10 (20%), and child-to-child transmission may have occurred in 1 of 6 (17%). Pediatric case patients most commonly reported headache (79%), sore throat (68%), and rhinorrhea (68%); symptoms had low positive predictive values, except measured fever (100%; 95% confidence interval [CI]: 44% to 100%). Compared with symptomatic adults, children were less likely to report cough (odds ratio [OR]: 0.15; 95% CI: 0.04 to 0.57), loss of taste (OR: 0.21; 95% CI: 0.06 to 0.74), and loss of smell (OR: 0.29; 95% CI: 0.09 to 0.96) and more likely to report sore throat (OR: 3.4; 95% CI: 1.04 to 11.18). CONCLUSIONS: Children and adults had similar secondary infection rates, but children generally had less frequent and severe symptoms. In two states early in the pandemic, we observed possible transmission from children in approximately one-fifth of households with potential to observe such transmission patterns. Copyright © 2021 by the American Academy of Pediatrics
Authors & Co-Authors
Laws, Rebecca L.
United States, Atlanta
Centers for Disease Control and Prevention
Fajans, Mark A.
United States, Atlanta
Centers for Disease Control and Prevention
Dawson, Patrick
United States, Atlanta
Centers for Disease Control and Prevention
Gharpure, Radhika V.
United States, Atlanta
Centers for Disease Control and Prevention
Owusu, Daniel
United States, Atlanta
Centers for Disease Control and Prevention
Pevzner, Eric S.
United States, Atlanta
Centers for Disease Control and Prevention
Battey, Katherine A.
United States, Atlanta
Centers for Disease Control and Prevention
Njuguna, Henry N.
United States, Atlanta
Centers for Disease Control and Prevention
Salvatore, Phillip P.
United States, Atlanta
Centers for Disease Control and Prevention
Vuong, Jeni T.
United States, Atlanta
Centers for Disease Control and Prevention
Gregory, Christopher J.
United States, Atlanta
Centers for Disease Control and Prevention
Dietrich, Elizabeth A.
United States, Atlanta
Centers for Disease Control and Prevention
Marcenac, Perrine
United States, Atlanta
Centers for Disease Control and Prevention
Matanock, Almea M.
United States, Atlanta
Centers for Disease Control and Prevention
Pray, Ian W.
United States, Atlanta
Centers for Disease Control and Prevention
United States, Madison
Wisconsin Department of Health Services
Bhattacharyya, Sanjib
United States, Milwaukee
City of Milwaukee Health Department
Dunn, Angela C.
United States, Salt Lake City
Utah Department of Health
Nabity, Scott A.
United States, Atlanta
Centers for Disease Control and Prevention
Binder, Alison M.
United States, Atlanta
Centers for Disease Control and Prevention
Lester, Sandra N.
United States, Atlanta
Centers for Disease Control and Prevention
Thornburg, Natalie J.
United States, Atlanta
Centers for Disease Control and Prevention
Hall, Aron J.
United States, Atlanta
Centers for Disease Control and Prevention
Fry, Alicia M.
United States, Atlanta
Centers for Disease Control and Prevention
Tate, Jacqueline E.
United States, Atlanta
Centers for Disease Control and Prevention
Tran, Cuc H.
United States, Atlanta
Centers for Disease Control and Prevention
Kirking, Hannah L.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 66
Authors: 26
Affiliations: 4
Identifiers
Doi:
10.1542/PEDS.2020-027268
ISSN:
00314005
Research Areas
Covid
Maternal And Child Health
Study Design
Case-Control Study