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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pre-operative trans-catheter arterial chemo-embolization increases hepatic artery thrombosis after liver transplantation – a retrospective study
Transplant International, Volume 31, No. 1, Year 2018
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Description
Little is known about nonsurgical risk factors for hepatic artery thrombosis (HAT) after liver transplantation (LT). We determined risk factors for HAT occurring within 90 days post-LT and analysed the effect of HAT on graft and patient survival. Donor and recipient demographics, surgery-related data and outcome in transplants complicated by thrombosis (HAT+) and their matched controls (HAT−) were compared. Risk factors were assessed by univariate logistic regression. Median (IQR) is given. A total of 25 HAT occurred among 1035 adult LT (1/1997–12/2014) and 50 controls were manually matched. Donor and recipient demographics were similar. Pre-LT trans-catheter arterial chemo-embolization (TACE) was more frequent in HAT+ (HAT+ 20% vs. HAT− 4%, P = 0.037). HAT+ had longer implantation [HAT+ 88 min (76–108) vs. HAT− 77 min (66–93), P = 0.028] and surgery times [HAT+ 6.25 h (5.18–7.47) vs. HAT− 5.25 h (4.33–6.5), P = 0.001]. Early graft dysfunction and sepsis were more frequent in HAT+ and hospitalization longer. TACE had the greatest odds ratio in unadjusted analysis (OR: 6, 95% CI: 1.07–33.53, P = 0.03). All but seven grafts were lost after HAT (HAT+ 72% vs. HAT− 36%, P = 0.003); however, patient survival was unaffected (HAT+ 79.8% vs. HAT− 76%, P = 0.75). LT candidates undergoing TACE are at risk of developing HAT early after transplant. © 2017 Steunstichting ESOT
Authors & Co-Authors
Jochmans, I.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Belgium, Leuven
Ku Leuven
Verslype, Chris
Belgium, Leuven
Ku Leuven
Maleux, Geert Albert
Belgium, Leuven
Ku Leuven
Laleman, Wim J.
Belgium, Leuven
Ku Leuven
van der Merwe, Schalk Willem
Belgium, Leuven
Ku Leuven
Cassiman, David M.
Belgium, Leuven
Ku Leuven
Nevens, Frederik
Belgium, Leuven
Ku Leuven
Monbaliu, Diethard
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Belgium, Leuven
Ku Leuven
Pirenne, Jacques
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Belgium, Leuven
Ku Leuven
Statistics
Citations: 11
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1111/tri.13046
ISSN:
09340874
Research Areas
Health System And Policy
Study Design
Cohort Study
Case-Control Study