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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph
Nature Communications, Volume 12, No. 1, Article 2931, Year 2021
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Description
Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indigenous populations, is associated with influenza-induced mortality, although the basis for this association is unclear. Here, we define CD8+ T-cell immune landscapes against influenza A (IAV) and B (IBV) viruses in HLA-A*24:02-expressing Indigenous and non-Indigenous individuals, human tissues, influenza-infected patients and HLA-A*24:02-transgenic mice. We identify immunodominant protective CD8+ T-cell epitopes, one towards IAV and six towards IBV, with A24/PB2550–558-specific CD8+ T cells being cross-reactive between IAV and IBV. Memory CD8+ T cells towards these specificities are present in blood (CD27+CD45RA− phenotype) and tissues (CD103+CD69+ phenotype) of healthy individuals, and effector CD27−CD45RA−PD-1+CD38+CD8+ T cells in IAV/IBV patients. Our data show influenza-specific CD8+ T-cell responses in Indigenous Australians, and advocate for T-cell-mediated vaccines that target and boost the breadth of IAV/IBV-specific CD8+ T cells to protect high-risk HLA-A*24:02-expressing Indigenous and non-Indigenous populations from severe influenza disease. © 2021, The Author(s).
Authors & Co-Authors
Nguyen, Thi H.O.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Koutsakos, Marios
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Luciani, Fabio
Australia, Sydney
Unsw Sydney
Saunders, Philippa M.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Brooks, Andrew G.
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Cheng, Allen C.
Australia, Clayton
Monash University
Australia, Melbourne
Alfred Health
Elliott, Michael Sowden
Australia, Sydney
The University of Sydney
Australia, Sydney
Royal Prince Alfred Hospital
Tangye, Stuart G.
Australia, Sydney
Garvan Institute of Medical Research
Australia, Sydney
St Vincent's Clinic
Flanagan, Katie L.
Australia, Launceston
Launceston General Hospital
Australia, Hobart
University of Tasmania
Australia, Clayton
Monash University
Australia, Melbourne
Rmit University
Rossjohn, Jamie
Australia, Clayton
Monash University
United Kingdom, Cardiff
Cardiff University School of Medicine
Gras, Stéphanie Le
Australia, Clayton
Monash University
Australia, Melbourne
La Trobe University
Davies, Jane
Australia, Darwin
Menzies School of Health Research
Tong, Stephen Y.C.
Australia, Melbourne
Royal Melbourne Hospital
Australia, Darwin
Menzies School of Health Research
Purcell, Anthony Wayne
Australia, Clayton
Monash University
Kedzierska, Katherine
Australia, Melbourne
The Peter Doherty Institute for Infection and Immunity
Statistics
Citations: 12
Authors: 15
Affiliations: 19
Identifiers
Doi:
10.1038/s41467-021-23212-x
ISSN:
20411723
Research Areas
Genetics And Genomics