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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017
Eurosurveillance, Volume 22, No. 8, Year 2017
Notification
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Description
We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity. © 2017, European Centre for Disease Prevention and Control (ECDC). All Rights Reserved.
Authors & Co-Authors
Harvala, Heli J.
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
United Kingdom, London
University College London
Frampton, Dan
United Kingdom, London
University College London
Grant, Paul R.
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Ferns, Ruth Bridget
United Kingdom, London
University College London
Kozlakidis, Zisis
United Kingdom, London
University College London
Kellam, P.
United Kingdom, London
Imperial College Faculty of Medicine
Morris, Lynn G.
United Kingdom, London
University College London
Hayward, Andrew C.
Unknown Affiliation
Nastouli, Eleni
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
United Kingdom, London
University College London
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Statistics
Citations: 31
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.2807/1560-7917.ES.2017.22.8.30466
ISSN:
1025496X