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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of diltiazem and atenolol in young, physically active men with essential hypertension
The American Journal of Cardiology, Volume 60, No. 13, Year 1987
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Description
The antihypertensive efficacy and effect on maximal exercise performance of diltiazem was evaluated and compared with atenolol in patients specifically selected on the basis of their being young and physically active. Diltiazem (sustained-release preparation, 90 mg twice daily) was administered to 14 patients (aged 33 ± 2 years) and atenolol (50 mg once daily) to 13 patients (aged 30 ± 2 years) with essential hypertension in a 16-week randomized, double-blind, parallel study. The 2 drugs had comparable antihypertensive effects at rest, with mean decreases of 18 and 17 mm Hg (p < 0.001) for supine and standing diastolic blood pressure (BP), respectively, during diltiazem treatment, and mean decreases of 21 and 18 mm Hg (p < 0.001) during atenolol treatment. During maximal graded exercise testing, systolic BP, diastolic BP, heart rate and heart rate-BP product were significantly reduced by both drugs. However, the reductions in systolic BP, heart rate and heart rate-BP product during exercise were considerably greater (p < 0.001) with atenolol than with diltiazem. Maximal exercise performance was essentially unchanged with diltiazem and slightly (3%, p < 0.05) reduced with atenolol. Thus, diltiazem is effective and well-tolerated single therapy for young patients with mild to moderate essential hypertension who lead a physically active life style and compares favorably with atenolol. © 1987.
Authors & Co-Authors
Myburgh, Dirk Petrus
South Africa, Pretoria
Institute for Aviation Medicine
United States, Dallas
Cooper Aerobics Center
Gordon, Neil F.
South Africa, Pretoria
Institute for Aviation Medicine
United States, Dallas
Cooper Aerobics Center
Statistics
Citations: 13
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/0002-9149(87)90359-6
ISSN:
00029149
Research Areas
Disability
Noncommunicable Diseases
Participants Gender
Male