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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Circulating plasmacytoid dendritic cells in acutely infected patients with hepatitis C virus genotype 4 are normal in number and phenotype
Journal of Infectious Diseases, Volume 202, No. 11, Year 2010
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Description
The incidence of hepatitis C virus (HCV) genotype 4 infection in Egypt provides a unique opportunity to study the innate immune response to symptomatic acute HCV infection. We investigated whether plasmacytoid dendritic cells (pDCs) are activated as a result of HCV infection. We demonstrate that, even during symptomatic acute infection, circulating pDCs maintained a similar precursor frequency and resting phenotype, compared with pDCs in healthy individuals. Moreover, stimulation with a Toll-like receptor 9 agonist resulted in an intact inflammatory response. These data support the growing consensus that pDCs are not directly activated by HCV and therefore are viable targets for immunotherapy throughout HCV infection. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Mansour, Hala
Egypt, Cairo
Ain Shams University
Laird, Melissa E.
France, Paris
Institut Pasteur, Paris
Saleh, Rasha
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Casrouge, Armanda
France, Paris
Institut Pasteur, Paris
Sharaf Eldin, Noha
Egypt, Cairo
Faculty of Medicine - Ain Shams University
A El-Kafrawy, Sherif Aly
Egypt, Cairo
Ain Shams University
Hamdy, Maha
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Decalf, Jérémie
France, Paris
Institut Pasteur, Paris
Rosenberg, Brad R.
United States, New York
Memorial Sloan-kettering Cancer Center
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
Abdel-Hamid, Mohamed A.
Egypt, Cairo
Ain Shams University
Egypt, Minya
Faculty of Medicine
Mohamed, Mostafa K.
Egypt, Cairo
Ain Shams University
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Albert, Matthew L.
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Rafik, Mona M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Statistics
Citations: 14
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1086/656777
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Locations
Egypt