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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV-1 populations in blood and breast milk are similar
Virology, Volume 330, No. 1, Year 2004
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Description
Mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) through breast milk is a significant mechanism of infection in many regions of the world. We compared the HIV-1 populations in paired blood and breast milk samples using a heteroduplex tracking assay (HTA) for the V1/V2 regions of env (V1/V2-HTA). V1/V2-HTA patterns were similar in the eight pairs of samples for which adequate template sampling could be demonstrated. No unique variants existed in either compartment, and differences detected in the relative abundance of variants between compartments were small, occurred among low abundance variants, and were not statistically significant. We also documented the impact of template sampling as a limiting feature in comparing two viral populations. The absence of unique variants and the lack of significant differences in the relative abundance of variants between these compartments support the conclusion that viruses in the blood plasma and breast milk are well equilibrated. © 2004 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Henderson, Gavin J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hoffman, Noah G.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Ping, Lihua
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Fiscus, Susan A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hoffman, Irving F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Kitrinos, Kathryn M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Banda, Topia
Malawi, Lilongwe
Lilongwe Central Hospital
Martinson, Francis E.A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Lilongwe Central Hospital
Kazembe, Peter Nicholas
Malawi, Lilongwe
Lilongwe Central Hospital
Chilongozi, David A.T.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Lilongwe Central Hospital
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Swanstrom, Ronald I.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States
Univ. N. C
Statistics
Citations: 42
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/j.virol.2004.09.004
ISSN:
00426822
Research Areas
Infectious Diseases
Maternal And Child Health