Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children
Journal of Clinical Pharmacology, Volume 43, No. 4, Year 2003
Notification
URL copied to clipboard!
Description
The authors conducted a randomized, double-blind, placebo-controlled trial of intravenous dichloroacetate (DCA) for the purpose of treating lactic acidosis in 124 West African children with severe Plasmodium falciparum malaria. Lactic acidosis independently predicts mortality in severe malaria, and DCA stimulates the oxidative removal of lactate in vivo. A single infusion of 50 mg/kg DCA was well tolerated. When administered at the same time as a dose of intravenous quinine, DCA significantly increased the initial rate and magnitude of fall in blood lactate levels and did not interfere with the plasma kinetics of quinine. The authors developed a novel population pharmacokinetic-pharmacodynamic indirect-response model for DCA that incorporated characteristics associated with disease reversal. The model describes the complex relationships among antimalarial treatment procedures, plasma DCA concentrations, and the drug's lactate-lowering effect. DCA significantly reduces the concentration of blood lactate, an independent predictor of mortality in malaria. Its prospective evaluation in affecting mortality in this disorder appears warranted. © 2003 the American College of Clinical Pharmacology.
Authors & Co-Authors
Agbenyega, Tsiri E.
Ghana, Kumasi
Kwame Nkrumah University of Science & Technology
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Planche, Tim David
United Kingdom, London
St George’s, University of London
Bedu-Addo, George
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Ansong, Daniel Ayirebi
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Owusu-Ofori, Alex K.
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Bhattaram, Venkatesh Atul
United States, Gainesville
University of Florida
Nagaraja, Nelamangala V.
United States, Gainesville
University of Florida
Shroads, Albert L.
United States, Gainesville
University of Florida
Henderson, George N.
United States, Gainesville
University of Florida
Hutson, Alan David
United States, Gainesville
University of Florida
Derendorf, H.
United States, Gainesville
University of Florida
Krishna, Prof Sanjeev
United Kingdom, London
St George’s, University of London
Stacpoole, Peter W.
United States, Gainesville
University of Florida
United States, Gainesville
University of Florida Academic Health Center
Statistics
Citations: 58
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1177/0091270003251392
Research Areas
Disability
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study