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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chromosomal aberration in the post-implantation embryos sired by tamoxifen treated male rats
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Volume 703, No. 2, Year 2010
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Description
Tamoxifen is a synthetic non-steroidal Selective Estrogen Receptor Modulator used in the treatment of breast cancer and in treatment of male fertility. Earlier studies from our laboratory had demonstrated an increase in post-implantation embryo loss following tamoxifen treatment to adult male rats at a dose of 0.4mg/kg/day for 60 days. The post-implantation loss occurred at around 9-10 days of gestation suggesting that paternal factors involved in embryo development were affected by tamoxifen treatment. The present study was done to determine if any chromosomal aberrations occurred in the embryos sired by tamoxifen treated male rats. Chromosomal aberrations induced by tamoxifen treatment to adult male rats in the bone marrow (F0 males) and in the embryos sired by these males (F1 progeny) were determined. In addition, the reproductive performance of the F1 progeny was assessed. A significant dose dependent reduction in mitotic activity in the bone marrow and embryonic cells was observed after tamoxifen treatment. In addition, tamoxifen also induced a significant dose dependent increase in the frequency of chromosomal aberrations, mainly gaps and breaks in bone marrow and embryonic cells. However, the embryos sired by the tamoxifen treated males had no effect on developmental milestones achieved and on their reproductive performance. The present study suggests that chromosomal aberrations observed in the embryos did not the affect their development until adulthood but could make the progeny of the tamoxifen treated males vulnerable to the development of adult onset diseases later in life. © 2010 Elsevier B.V.
Authors & Co-Authors
Kedia-Mokashi, Neelam
India, Mumbai
National Institute for Research in Reproductive Health India
El-Makawy, Aida Ibrahim
Egypt, Giza
National Research Centre
Saxena, Madhurima
India, Mumbai
National Institute for Research in Reproductive Health India
Balasinor, N. H.
India, Mumbai
National Institute for Research in Reproductive Health India
Statistics
Citations: 10
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.mrgentox.2010.08.016
ISSN:
13835718
Research Areas
Cancer
Sexual And Reproductive Health
Participants Gender
Male