Usefulness of aerobic exercise in managing the proinflammatory status in adults with metabolic syndrome

The present study was designed to determine the influence of regular exercise on proinflammatory biomarkers in young adults with metabolic syndrome.To get this goal, sixty young adult men with metabolic syndrome according to the criteria reported by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) volunteered for this study. Fourty-five were randomly included in experimental group to perform a 12-week aerobic training program, 3 days/week, consisting of warm up (10 min), main part (20-35 min [increasing 5 minutes each three weeks]) at a work intensity of 60-75% of peak heart rate (increasing 5% each three weeks) and cool-down (10 min).Control group included 15 age, sex and BMI-matched men with metabolic syndrome that will not perform any training program. Our protocol was approved by an institutional ethic committee. Plasmatic cytokine levels (Tumor-Necrosis-Factor [TNF-α]; Interleukin-1 [IL-1β]; Interleukin-6 [IL-6]) were determined by ELISA twice: firstly 72-h before starting the program (pre-test) and finally 72-h after its ending (post-test). Fat mass percentage was determined by bioelectric-impendance method.When compared to baseline plasmatic cytokine levels were decreased significantly after being exercised. On the contrary no changes were reported in controls. We concluded a 12-week training program reduced proinflammatory biomarkers in male adults with metabolic syndrome.