Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of HSV-2 serostatus on acquisition of HIV by young men: Results of a longitudinal study in orange farm, South Africa
Journal of Infectious Diseases, Volume 199, No. 7, Year 2009
Notification
URL copied to clipboard!
Description
Background. The objectives of this study were to assess the impact among young men of herpes simplex virus type 2 (HSV-2) status on the acquisition of human immunodeficiency virus (HIV) and on the protective effect of male circumcision against HIV acquisition. Methods. We used data collected during a male circumcision trial conducted in Orange Farm, South Africa. We estimated adjusted incidence rate ratios (IRRs) for HIV acquisition, using survival analysis and background characteristics, HSV-2 status, male circumcision status, and sexual behavior as covariates. Results. Compared with subjects who remained HSV-2 negative throughout the study, subjects who were HSV-2 positive at enrollment had an adjusted IRR of 3.3 (95% confidence interval [CI], 1.5-7.4; P = .004), and those who became HSV-2 positive during follow-up had an adjusted IRR of 7.0 (95% CI, 3.9-12.4; P < .001). The population fraction of incident HIV infection attributable to HSV-2 was 27.8% (95% CI, 17.7%-37.2%). Intention-to-treat analysis of the protective effect of male circumcision on HIV acquisition was the same among men with and men without HSV-2 (0.38 vs. 0.37; P = .93). Conclusions. This study shows that HSV-2 has a substantial impact on HIV acquisition among young South African men. It suggests that HSV-2 infection enhances HIV acquisition and is responsible for-25% of incident cases of HIV infection. However, the protective effect of male circumcision against HIV acquisition appears independent of HSV-2 serostatus. Trial registration. ClinicalTrials.gov identifier: NCT00122525. © 2009 by the Infectious Diseases Society of America.
Authors & Co-Authors
Joelle, Sobngwi
France, Paris
Inserm
Taljaard, Dirk J.
Unknown Affiliation
Lissouba, Pascale
France, Paris
Inserm
Zarca, Kevin
France, Paris
Inserm
Puren, Adrian
South Africa, Johannesburg
National Institute for Communicable Diseases
Lagarde, Emmanuel
France, Paris
Inserm
Auvert, Bertran
France, Paris
Inserm
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Versailles
Université de Versailles Saint-quentin-en-yvelines
Statistics
Citations: 165
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1086/597208
ISSN:
00221899
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
South Africa
Participants Gender
Male