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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Good performance of rapid prostate-specific antigen test for detection of semen exposure in women: Implications for qualitative research
Sexually Transmitted Diseases, Volume 36, No. 8, Year 2009
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Description
BACKGROUND: Prostate-specific antigen (PSA) is a valid biomarker of semen exposure in women and has been used to assess reliability of self-reported sexual behavior as well as serve as a proxy measure for condom efficacy. Quantitative PSA tests are expensive and require specialized equipment. A simple, rapid, and inexpensive test for PSA would facilitate semen biomarker evaluation in a variety of research settings. This study evaluated the performance of a rapid PSA test compared with a quantitative assay to identify semen in vaginal swab specimens. METHODS: We tested 581 vaginal swabs collected from 492 women participating in 2 separate research studies in Bangladesh and Zimbabwe. PSA in vaginal secretions was detected using the quantitative IMx (Abbott Laboratories) assay and the ABAcard p30 (Abacus Diagnostics) rapid immunochromatographic strip test. RESULTS: The ABAcard test was 100% sensitive (95% confidence interval [CI], 98%-100%) and 96% specific (95% CI, 93%-97%) compared with the quantitative test in detecting >1.0 ng PSA/mL vaginal swab eluate. Rapid PSA results were semiquantitative and correlated well with PSA concentrations (κ = 0.88; 95% CI, 0.85-0.90). CONCLUSION: Rapid PSA detection requires no instrumentation and can be performed easily and economically. Having rapid PSA results available immediately following interview provides opportunities to explore discrepancies between the objective marker of recent semen exposure and self-reported behaviors. © Copyright 2009 American Sexually Transmitted Diseases Association.
Authors & Co-Authors
Hobbs, Marcia M.
United States, Chapel Hill
Unc School of Medicine
Steiner, Markus J.
United States, Durham
Fhi 360
Rich, Kimberly D.
United States, Chapel Hill
Unc School of Medicine
Gallo, Maria F.
United States, Atlanta
Centers for Disease Control and Prevention
Alam, Anadil B.M.Saiful
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Rahman, Motiur D.Abdur
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Menezes, Prema
United States, Chapel Hill
Unc School of Medicine
Chipato, Tsungai
Zimbabwe, Harare
University of Zimbabwe
Warner, Lee
United States, Atlanta
Centers for Disease Control and Prevention
MacAluso, Maurizio
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 36
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1097/OLQ.0b013e3181a2b4bf
ISSN:
01485717
Research Areas
Sexual And Reproductive Health
Study Approach
Qualitative
Quantitative
Study Locations
Zimbabwe
Participants Gender
Female