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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association between the - 2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients
Clinica Chimica Acta, Volume 390, No. 1-2, Year 2008
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Description
Background: Monocyte chemoattractant protein-1 (MCP-1; gene name CCL2) has been suggested to play an important role in the initiation of atherosclerosis by recruiting monocytes to sites of injured endothelium. Recently, single nucleotide polymorphisms (SNPs) in the MCP-1 regulatory region have been identified. Controversial results regarding the association of the - 2518G/A polymorphism of the MCP-1 gene with coronary artery disease (CAD) have been reported. In the present study, we examined a possible association between the - 2518G/A polymorphism of the MCP-1 gene and myocardial infarction (MI) in a sample of the Tunisian population. Methods: A total of 319 Tunisian patients with MI and 467 healthy controls were included in the study. The SNP of the MCP-1 gene was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Patients with MI had significantly higher frequency of the AG + GG genotypes compared to controls [42.9% vs. 35.8%; OR (95%CI), 1.34 (1.00-1.79); p = 0.04]. The MI patient group showed a significant higher frequency of the G allele compared to the controls [0.242 vs. 0.195; OR (95%CI), 1.31(1.02-1.68), p = 0.03]. The association between the - 2518G/A polymorphism of the MCP-1 gene and MI was no longer significant after adjustment for other well-established risk factors. Conclusion: The present study showed a significant but not independent association between the - 2518G/A polymorphism of the MCP-1 gene (presence of G allele) and MI in the Tunisian population. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Jemaa, Riadh
Tunisia, Tunis
Hôpital la Rabta
Rojbani, Hajer
Tunisia, Tunis
Hôpital la Rabta
Kallel, Amani
Tunisia, Tunis
Hôpital la Rabta
Ben Ali, Samir
Tunisia, Tunis
Hôpital la Rabta
Feki, Moncef
Tunisia, Tunis
Hôpital la Rabta
Chabrak, Sonia
Tunisia, Tunis
Hôpital la Rabta
Allal-Elasmi, Monia
Tunisia, Tunis
Hôpital la Rabta
Taieb, Samah Haj
Tunisia, Tunis
Hôpital la Rabta
Sanhaji, Haïfa
Tunisia, Tunis
Hôpital la Rabta
Souheil, Omar
Tunisia, Tunis
Hôpital la Rabta
Mechmèche, Rachid
Tunisia, Tunis
Hôpital la Rabta
Kâabachi, Naziha
Tunisia, Tunis
Hôpital la Rabta
Statistics
Citations: 12
Authors: 12
Affiliations: 1
Identifiers
Doi:
10.1016/j.cca.2008.01.004
ISSN:
00098981
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study