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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A fatal case of oleandrin poisoning
Forensic Science International, Volume 179, No. 2-3, Year 2008
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Description
The study presents a case of fatal poisoning with oleander leaves in an adult diabetic male. After repeated vomiting, and gastrointestinal distress the patient was admitted at the hospital with cardiac symptoms 1 h after the ingestion. Urine samples were assayed immunochemically and by GC-MS for drugs of abuse and for general toxicological screen. Blood was analyzed for alcohol and volatiles by static head space GC-MS. Blood and oleander leaves were analyzed by LC-MS/MS for oleandrin and related compounds, the main cardiac glycosides of Nerium oleander. Oleandrin was detected by LC-MS/MS in the blood sample at a concentration of ∼10 ng/ml. Another cardiac glycoside with pseudo-molecular ion of m/z 577, a likely structural isomer of oleandrin, was also detected in the blood and oleander leaves. However, by using the response as a function of concentration for oleandrin, this cardiac glycoside was roughly estimated at a concentration of ∼10 ng/ml in the deceased blood. This would give a total fatal blood concentration of cardiac glycosides of about ∼20 ng/ml in the deceased blood. © 2008 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Wasfi, Ibrahim Abdel Rahman
United Arab Emirates, Abu Dhabi
Forensic Science Laboratory Abu Dhabi
Zorob, Omar
United Arab Emirates, Abu Dhabi
Forensic Science Laboratory Abu Dhabi
Al-Katheeri, Nawal Abdulla
United Arab Emirates, Abu Dhabi
Forensic Science Laboratory Abu Dhabi
Al Awadhi, Anwar M.
United Arab Emirates, Abu Dhabi
Forensic Science Laboratory Abu Dhabi
Statistics
Citations: 45
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.forsciint.2008.05.002
ISSN:
03790738
Research Areas
Health System And Policy
Noncommunicable Diseases
Substance Abuse
Participants Gender
Male