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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda
Sexually Transmitted Diseases, Volume 34, No. 7, Year 2007
Notification
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Description
OBJECTIVE: The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda. STUDY DESIGN: Between 2002 and 2003, women from a population-based cohort participated in an HPV study. Women collected self-administered vaginal swabs and were also offered a pelvic examination, which included physician-collected cervical samples. METHODS: Hybrid-capture 2 was used to determine carcinogenic HPV status. Polymerase chain reaction was used to determine HPV genotypes. Unweighted κ statistics were used to determine agreement. RESULTS: Compliance with self-collected swabs was ≥86%; however, only 51% accepted a pelvic examination. Carcinogenic HPV prevalence was 19% in self-collected and 19% in physician-collected samples. Agreement among paired observations was 92% with a κ of 0.75. Kappa between self- and physician-collected samples was similar in HIV strata (k = 0.71 and 0.75 for HIV-positive and HIV-negative, respectively). DISCUSSION: In this community-based setting, detection of carcinogenic HPV was comparable among self- and physician-administered samples. Self-collection is a feasible and accurate means of obtaining HPV samples from women in resource-poor settings or persons reluctant to undergo a pelvic examination. © Copyright 2007 American Sexually Transmitted Diseases Association.
Authors & Co-Authors
Safaeian, Mahboobeh
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
United States, Rockville
National Cancer Institute Nci
Kiddugavu, Mohammed G.
Uganda, Entebbe
Uganda Virus Research Institute
Gravitt, Patti E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Ssekasanvu, Joseph
Uganda, Entebbe
Uganda Virus Research Institute
Murokora, Daniel
Uganda, Entebbe
Uganda Virus Research Institute
Sklar, Marc
United States, New York
Mailman School of Public Health
Serwadda, David Musoke
Uganda, Kampala
Makerere University
Wawer, Maria J.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Shah, Keerti V.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gray, Ronald H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 82
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1097/01.olq.0000243623.67673.22
ISSN:
01485717
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Uganda
Participants Gender
Female