Simultaneous determination of doxorubicin and dasatinib as two breast anticancer drugs uses an amplified sensor with ionic liquid and ZnO nanoparticle

The voltammetric behavior of doxorubicin at a ZnO nanoparticle/1-butyl-3-methylimidazolium tetrafluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) has been investigated. For the goal, ZnO-NPs were biosynthesized by celery extract in aqueous solution. The ZnO-NPs/BMTFB/CPE exhibits a good promoting effect on the oxidation response of doxorubicin. After optimization of pH condition, ZnO-NPs/BMTFB/CPE exhibits two separated oxidation signals for simultaneous analysis of doxorubicin and dasatinib with ∆E ~300 mV. The oxidation currents showed linear relation with doxorubicin or dasatinib concentration in the ranges of 0.07–500 μM and 1.0–1200 μM, respectively. We detected limit of detection 9.0 nM and 0.5 μM for doxorubicin and dasatinib, respectively. The ZnO-NPs/BMTFB/CPE has been applied to the analysis of doxorubicin and dasatinib in injection and pharmaceutical serum samples. © 2018 Elsevier B.V.