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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Coinfection with herpes simplex virus type 2 is associated with reduced HIV-specific T cell responses and systemic immune activation
Journal of Infectious Diseases, Volume 197, No. 10, Year 2008
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Description
Background. Chronic coinfection with herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus (HIV) has been associated with an increased HIV viral load and more rapid disease progression, perhaps related to HSV-2-associated alterations in host immunity. Methods. Studies were nested within (1) a cross-sectional study of men coinfected with HIV and HSV-2 and (2) women not infected with HIV, both before and after HSV-2 acquisition. HSV-2 infection status was determined by ELISA. HIV-specific CD8+ T cell epitopes were mapped, and proliferation of HIV-specific cells was also assessed. Systemic inflammatory and regulatory T cell populations were assayed by flow cytometry. Results. The breadth of both the HIV-specific CD8+ T cell interferon-γ and proliferative responses was reduced in participants coinfected with HIV and HSV-2, independent of the HIV plasma viral load and CD4+ T cell count, and the magnitude of the responses was also reduced. HSV-2 infection in this group was associated with increased T cell CD38 expression but not with differences in the proportion of CD4+ FoxP3+ regulatory T cells. However, in women not infected with HIV, acquisition of HSV-2 was associated with an increase in the proportion of regulatory T cells. Conclusions. HSV-2 coinfection was associated with reduced HIV-specific T cell responses and systemic inflammation. The immune effects of HSV-2 may underlie the negative impact that this coinfection has on the clinical course of HIV infection. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Sheth, Prameet M.
Canada, Toronto
University of Toronto
Sunderji, Sherzana
Canada, Toronto
University of Toronto
Shin, Lucy Y.
Canada, Toronto
University of Toronto
Rebbapragada, Anuradha
Canada, Toronto
University of Toronto
Huibner, Sanja
Canada, Toronto
University of Toronto
Kimani, Joshua
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
MacDonald, Kelly S.
Canada, Toronto
University of Toronto
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Ngugi, Elizabeth N.
Kenya, Nairobi
University of Nairobi
Bwayo, Job J.
Kenya, Nairobi
University of Nairobi
Moses, Stephen
Canada, Winnipeg
University of Manitoba
Kovacs, Colin M.
Canada, Toronto
Canadian Immunodeficiency Research Collaborative
Loutfy, Mona
Canada, Toronto
Canadian Immunodeficiency Research Collaborative
Kaul, Rupert
Canada, Toronto
University of Toronto
Canada, Toronto
University Health Network University of Toronto
Kenya, Nairobi
University of Nairobi
Statistics
Citations: 67
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1086/587697
ISSN:
00221899
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Male
Female