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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Tolerance of Kenyan Schistosoma mansoni to oxamniquine
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 81, No. 5, Year 1987
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Description
Although 30 mg/kg oxamniquine produced high levels (85·5 to 99·5%) of egg reduction in Kenyan children infected with Schistosoma mansoni after a single oral treatment, cure rates from children at Mwea in Kirinyaga district were lower than those from Machakos (58% v. 74%). Redosing uncured children confirmed this lower cure rate (36% v. 83%). Isolates from infected children were passaged into mice and dosed with oxamniquine. Lower than expected reductions in worm numbers were obtained, suggesting that oxamniquine tolerant S. mansoni are present in the normal worm population in Kenya. It is concluded that mass use of oxamniquine at 30 mg/kg may produce problems of drug resistance. © 1987.
Authors & Co-Authors
Coles, Gerald C.
United States, Amherst
University of Massachusetts Amherst
Mutahi, W. T.
Kenya, Nairobi
University of Nairobi
Kinoti, George K.
Kenya, Nairobi
University of Nairobi
Bruce, John I.
United States, Lowell
University of Massachusetts Lowell
Katz, Naftale
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Statistics
Citations: 52
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/0035-9203(87)90032-0
ISSN:
00359203
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Kenya