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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Interethnic differences in carriage of haemoglobin AS and Fcγ receptor IIa (CD32) genotypes in children living in eastern Sudan
Acta Tropica, Volume 105, No. 2, Year 2008
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Description
Fulani and Masaleit, two sympatric ethnic groups in eastern Sudan, are characterized by marked differences in susceptibility to Plasmodium falciparum malaria. It has been suggested that sickle cell trait carriage may protect from the most severe forms of malaria. Previously, we have shown that FcγRIIa polymorphism is associated with the outcome of malaria disease. The present study aimed at determining whether the two tribes differ in the frequency of FcγRIIa and Hb AS genotypes. For this, genotyping of FcγRIIa and Hb AS in 70 Fulani and 70 Masaleit age- and sex-matched subjects was conducted. The frequency of FcγRIIa H/H131 genotype was higher in the Fulani as compared to the Masaleit group (40.0% versus 14.3%; adjusted odd ratio [OR] = 3.05, 95% confidence interval [CI] = 1.19-7.82 and P = 0.02), while the R/R131 genotype was significantly higher in the Masaleit group (14.3% for Fulani versus 45.0% for Masaleit; adjusted OR = 0.26, 95% CI = 0.11-0.64 and P < 0.01). With regard to FcγRIIa allele frequencies, there were significant differences between the Fulani and Masaleit ethnic groups. Thus, the H131 allele was more frequent than the R131 among Fulani children (0.63 versus 0.37, OR = 3.23, 95% CI = 1.93-5.45 and P < 0.001). The frequency of the Hb AS genotype was lower in the Fulani compared to the Masaleit group (15.7% versus 30.0%, respectively, adjusted OR = 0.02, CI = 0.01-0.18 and P < 0.01). These data suggest that FcγRIIa and Hb AS polymorphisms may contribute to the clinical outcome of malaria. We conclude that the H/H131 genotype and H131 allele rather than Hb AS genotype (sickle cell trait patients) appear to associate with the Fulani ethnic group. © 2007 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Nasr, A. A.
Sweden, Stockholm
Institutionen För Molekylär Biovetenskap, Wenner-grens Institut
ElGhazali, Gehad Eltayeb B.
Sudan, Khartoum
Khartoum University
Saudi Arabia, Riyadh
Faculty of Medicine
Giha, Hayder Ahmed
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Troye-Blomberg, Marita
Sweden, Stockholm
Institutionen För Molekylär Biovetenskap, Wenner-grens Institut
Berzins, Klavs
Sweden, Stockholm
Institutionen För Molekylär Biovetenskap, Wenner-grens Institut
Statistics
Citations: 31
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/j.actatropica.2007.10.003
ISSN:
0001706X
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Locations
Sudan