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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Sustained glycolytic oscillations in individual isolated yeast cells
FEBS Journal, Volume 279, No. 16, Year 2012
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Description
Yeast glycolytic oscillations have been studied since the 1950s in cell-free extracts and intact cells. For intact cells, sustained oscillations have so far only been observed at the population level, i.e. for synchronized cultures at high biomass concentrations. Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. This is the first time that sustained limit-cycle oscillations have been demonstrated in isolated yeast cells. © 2012 FEBS.
Authors & Co-Authors
Gustavsson, Anna Karin
Sweden, Gothenburg
Göteborgs Universitet
Van Niekerk, David D.
South Africa, Stellenbosch
Stellenbosch University
Adiels, Caroline B.
Sweden, Gothenburg
Göteborgs Universitet
Du Preez, Franco B.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Goksor̈, Mattias
Sweden, Gothenburg
Göteborgs Universitet
Snoep, Jacky L.
South Africa, Stellenbosch
Stellenbosch University
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
United Kingdom, Manchester
The University of Manchester
Statistics
Citations: 73
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1111/j.1742-4658.2012.08639.x
ISSN:
1742464X
e-ISSN:
17424658
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study