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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia
American Journal of Human Genetics, Volume 81, No. 4, Year 2007
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Description
The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in numerous studies of several populations in Asia and Europe. In a review of literature from the past 30 years, we have identified studies that report allele frequencies of this polymorphism for 131 population samples from many different parts of the world. The derived ADH1B*47His allele reaches high frequencies only in western and eastern Asia. To pursue this pattern, we report here new frequency data for 37 populations. Most of our data are from South and Southeast Asia and confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia. © 2007 by The American Society of Human Genetics. All rights reserved.
Authors & Co-Authors
Lǐ, Hui
United States, New Haven
Yale School of Medicine
Mukherjee, Namita
United States, New Haven
Yale School of Medicine
Soundararajan, Usha
United States, New Haven
Yale School of Medicine
Tárnok, Zsanett
Hungary, Budapest
Institute of Medical Chemistry
Barta, Csaba
Hungary, Budapest
Semmelweis Egyetem
Khaliq, Shagufta
Pakistan, Karachi
University of Karachi
Kajuna, Sylvester L.B.
Tanzania, Dar es Salaam
Hubert Kairuki Memorial University
Mehdi, Syed Qasim
Pakistan, Karachi
University of Karachi
Kidd, Judith R.
United States, New Haven
Yale School of Medicine
Kidd, Kenneth K.
United States, New Haven
Yale School of Medicine
Statistics
Citations: 90
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1086/521201
ISSN:
00029297
Research Areas
Genetics And Genomics
Substance Abuse
Study Design
Cross Sectional Study