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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells
Journal of Receptors and Signal Transduction, Volume 34, No. 3, Year 2014
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Description
A creatinine metabolite, 5-hydroxy-1-methylhydantoin (HMH: NZ-419), a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. In the current study, we demonstrate that HMH modulates the effects of glucose and bradykinin (BK) in vascular smooth muscle cell (VSMC). HMH a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. HMH inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that HMH may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties. © 2014 Informa Healthcare USA, Inc.
Authors & Co-Authors
Ienaga, Kazuharu
Japan, Osaka
Nippon Zoki Pharmaceutical Co., Ltd.
Sohn, Mimi
United States, Charleston
Medical University of South Carolina
Naiki, Mitsuru
Japan, Osaka
Nippon Zoki Pharmaceutical Co., Ltd.
Jaffa, Ayad A.
United States, Charleston
Medical University of South Carolina
Lebanon, Beirut
American University of Beirut
Statistics
Citations: 4
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.3109/10799893.2013.876039
ISSN:
10799893
e-ISSN:
15324281
Research Areas
Health System And Policy
Noncommunicable Diseases
Violence And Injury