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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evaluation of paradoxical TB-associated IRIS with the use of standardized case definitions for resource-limited settings
Journal of the International Association of Physicians in AIDS Care, Volume 9, No. 2, Year 2010
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Description
Objective: Standardized case definitions have recently been proposed by the International Network for the Study of HIV-associated immune reconstitution inflammatory syndrome (INSHI; [IRIS]) for use in resource-limited settings. We evaluated paradoxical tuberculosis (TB)-associated IRIS in a large cohort from a TB endemic setting with the use of these case definitions. Design: A retrospective cohort study. Method: We reviewed records from 1250 South African patients who initiated antiretroviral therapy (ART) over a 5-year period. Results: A total of 333 (27%) of the patients in the cohort had prevalent TB at the initiation of ART. Of 54 possible paradoxical TB-associated IRIS cases, 35 fulfilled the INSHI case definitions (11% of TB cases). Conclusions: INSHI-standardized case definitions were used successfully in identifying paradoxical TB-associated IRIS in this cohort and resulted in a similar proportion of TB IRIS cases ( %) as that reported in previous studies from resource-limited settings (8%-l3%). This case definition should be evaluated prospectively. © The Author(s) 2010.
Authors & Co-Authors
Eshun-Wilson, Ingrid
South Africa, Tygerberg
Tygerberg Hospital
Havers, Fiona P.
United States, Baltimore
The Johns Hopkins Hospital
Nachega, J. B.
South Africa, Stellenbosch
Stellenbosch University
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Prozesky, Hans (Hw)
South Africa, Tygerberg
Tygerberg Hospital
Taljaard, J. J.
South Africa, Tygerberg
Tygerberg Hospital
Zeier, Michèle Desiré
South Africa, Tygerberg
Tygerberg Hospital
Cotton, Mark Fredric
South Africa, Tygerberg
Tygerberg Hospital
Simon, Gary L.
United States, Washington, D.c.
The George Washington University
Soentjens, Patrick H.P.
Belgium, Brussels
Queen Astrid Military Hospital
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Statistics
Citations: 31
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1177/1545109710361537
ISSN:
15451097
e-ISSN:
15570886
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative