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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Role of environment and behaviour in familial resemblances of Plasmodium falciparum infection in a population of Senegalese children
Microbes and Infection, Volume 6, No. 1, Year 2004
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Description
Despite the importance of both environment and behaviour in vector-borne disease epidemiology, these factors are unable to explain alone the distribution of cases in a community and the diversity of clinical presentations, suggesting the involvement of more individual factors such as age, sex, immunity or genetic background. The existence of a genetic factor involved in the susceptibility/resistance to a disease can be suspected by the demonstration of a familial aggregation of cases or by the stability over time of infectious status (infected vs. uninfected; mean level of parasite density (PD), etc.). These familial resemblances can be explained by shared environment, family habits and behaviours (use of bed nets, field activities, etc.). In this preliminary study, we essentially investigated the influence of environment and behaviour on Plasmodium falciparum infection levels and reported the effects of these factors on the existence of familial resemblances. Our results are consistent with the existence of familial resemblances for both the level of P. falciparum infection and the qualitative infection status (QIS) (infected vs. uninfected) that seem to be more related to shared behaviour and environment than to a genetic factor. However, although familial resemblances decreased significantly when adjusted for shared behaviour and environment, this decrease is around 12% for the variability between families, against only 4.5% of that within families. Furthermore, we also demonstrated that the QIS is remarkably stable over time. Both these results are consistent with the hypothesis of the existence of a strong and complex individual factor involved in the control of infection status. © 2003 Elsevier SAS. All rights reserved.
Authors & Co-Authors
Garcia, André
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Dieng, Allé Baba
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Rouget, Florence
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Migot-Nabias, Florence
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Le-Hesran, Jean Yves
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Gaye, Oumar H.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Statistics
Citations: 17
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.micinf.2003.09.021
ISSN:
12864579
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Qualitative