Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Human herpesvirus type 8 variants circulating in Europe, Africa and North America in classic, endemic and epidemic Kaposi's sarcoma lesions during pre-AIDS and AIDS era
Virology, Volume 398, No. 2, Year 2010
Notification
URL copied to clipboard!
Description
Human herpesvirus-8 (HHV-8) variants have been found heterogeneously distributed among human populations living in diverse geographic regions, but their differential pathogenicity in Kaposi's sarcoma development remains controversial. In the present study, HHV-8 variant distribution has been analyzed in classic, iatrogenic, endemic as well as epidemic Kaposi's sarcoma (KS) during pre-AIDS and AIDS period (1971-2008) in countries with different KS incidence rate. DNA samples from cutaneous KS lesions of 68 patients living in Africa (n = 23, Cameroon, Kenya and Uganda), Europe (n = 34, Greece and Italy) and North America (n = 11) have been subjected to PCR amplification of HHV-8 ORF 26, T0.7, K1 and K14.1/15, followed by direct nucleotide sequencing and phylogenetic analysis. Among the 23 African samples, the majority of HHV-8 ORF 26 variants clustered with the subtype R (n = 12) and B (n = 5). Conversely, the viral sequences obtained from 45 European and North European tumors belonged mainly to subtype A/C (n = 36). In general, HHV-8 and K1 variant clustering paralleled that of ORF 26 and T0.7. Genotyping of the K14.1/15 loci revealed a large predominance of P subtype in all tumors. In conclusion, comparison of the HHV-8 sequences from classic or endemic versus AIDS-associated KS showed a strong linkage of the HHV-8 variants with specific populations, which has not changed during AIDS epidemic. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Tornesello, Maria Lina
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Biryahwaho, Benon
Uganda, Entebbe
Uganda Virus Research Institute
Downing, Robert G.
Uganda, Entebbe
Uganda Virus Research Institute
Hatzakis, Angelo
Greece, Athens
National and Kapodistrian University of Athens
Alessi, Elvio
Italy, Milan
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico
Cusini, Marco
Italy, Milan
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico
Ruocco, Vincenzo
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Katongole-Mbidde, Edward
Uganda, Entebbe
Uganda Virus Research Institute
Loquercio, Giovanna
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Buonaguro, Luigi
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Buonaguro, Franco Maria
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Statistics
Citations: 61
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1016/j.virol.2009.12.005
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Locations
Cameroon
Kenya
Uganda