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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Protein extracted from Moringa oleifera Lam. Leaves: Bio-evaluation and characterization as suitable plant-based meat-protein alternative
Regulatory Toxicology and Pharmacology, Volume 146, Article 105536, Year 2024
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Description
This study aimed to isolate and characterize moringa leaf protein (MLP) via HPLC and evaluate its consumption's effects through rat model. Four groups of Albino Wistar rats (n = 25 each) along with a control group (n = 25) were acclimatized. The isolated MLP was added to the basal diet (casein; control) in various percentages (25, 50, 75, 100%) for a 21-day experimental period. On three intervals (1st, 11th, 21st days), blood samples were collected and subjected for hematological and biochemical examination (Renal Function Test (RFT), Liver Function Test (LFT)). MLP contained a variety of essential and non-essential amino acids in substantial amounts. The Protein Efficiency Ratio (PER) of 50% MLP-treated group was the highest (1.72) among MLP treatments. Increases in feed intake and weight were observed in treated rats compared to the control. The hematological profile of the rats revealed increases in Hemoglobin (Hb) (7.9–14.0%), White Blood Cell (WBC) (35.9–51.5%), Red Blood Cell (RBC) (17.1–22.2%), Hematocrit (HCT) (13.1–22.9%), and platelets levels (36.5–40.6%) from day 1. Protein isolates decreased liver parameters but resulted in non-significant changes in liver and kidney functions in rats. Further investigation is needed to determine the safe daily intake of MLP. © 2023 The Authors
Authors & Co-Authors
Javed, Muhammad Sameem
Pakistan, Multan
Bahauddin Zakariya University
Amjad, Adnan
Pakistan, Multan
Bahauddin Zakariya University
Sardar, Hasan
Pakistan, Multan
Bahauddin Zakariya University
Anwar, Muhammad Junaid
Pakistan, Multan
Bahauddin Zakariya University
Abou Fayssal, Sami
Bulgaria, Sofia
University of Forestry
Lebanon, Beirut
Université Libanaise
Kumar, Pankaj
India, Haridwar
Gurukula Kangri Deemed to be University
India, Dehradun
Society for Agroenvironmental Sustainability
Mohammad Wabaidur, Saikh Mohammad
Saudi Arabia, Riyadh
King Saud University
Okla, Mohammad Khair
Saudi Arabia, Riyadh
King Saud University
Saleh, Ibrahim A.
Jordan, Zarqa
Zarqa University
Abdelgawad, Hamada R.
Belgium, Antwerpen
Universiteit Antwerpen
Statistics
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1016/j.yrtph.2023.105536
ISSN:
02732300
Study Design
Randomised Control Trial