Distribution of HLA‐DQA1, ‐DQB1 and DRB1 alleles in black IDDM patients and controls from Zimbabwe

Abstract: We have used the XI Histocompatibility Workshop sequence‐specific oligonucleotide probes to determine the DRB1, DQA1 and DQB1 genotypes by dot‐blot hybridization of polymerase chain reaction (pcr)‐amplified material from a homogenous black population in Zimbabwe. The DR4 subtype DRB1*0405, the DR3 subtype DRB1*0301, DQB1*0201 and DQB1*0302 and DQA1*0301 and DQA1*0501 were significantly increased in the IDDM group compared to the controls, whereas DRB1*11, DQB1*0602 and DQA1*0102 were significantly decreased. Taken together, the data show that susceptibility and resistance to IDDM are associated both with particular haplotypes and DQA1‐DQB1 heterodimers without one or other being overriding., Zimbabwean Copyright © 1992, Wiley Blackwell. All rights reserved