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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Use of triclabendazole for treatment of patients co-infected by Fasciola spp. and S. mansoni in Behera Governorate, Egypt
Parasitology Research, Volume 102, No. 4, Year 2008
Notification
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Description
Praziquantel is still very effective for the treatment of schistosomiasis, but there are rising concerns on the potential risk of developing resistances because of the extensive use of this drug. Triclabendazole, a systemic anthelmintic, is very effective against other trematodes such as Paragonimus spp. and Fasciola spp. It has been reported to be effective in vitro and in experimental animals against Schistosoma mansoni. However, its antischistosomal efficacy in humans has not yet been evaluated. The objective of the study was to evaluate the efficacy of triclabendazole at the dosage currently used for the treatment of human fascioliasis (10mg/kg body weight) in subjects co-infected with S. mansoni and Fasciola spp. The study was carried out in Behera, a highly endemic area for both parasites, by personnel of the Egyptian Ministry of Health and Population. Ten subjects (m = 4, f = 6; age, 8-58years), who were infected at the same time by Fasciola spp. and S. mansoni, were enrolled. Six weeks after therapy, seven subjects were still excreting ova of S. mansoni, whereas none was excreting Fasciola spp. ova. At the given dosage, triclabendazole appeared not to be sufficiently effective in the treatment of S. mansoni. © 2007 Springer-Verlag.
Authors & Co-Authors
Barduagni, Paolo
Italy, Rome
Ministry of Foreign Affairs
Hassanein, Yehia Abd El Wahab
Egypt, Cairo
Egyptian Ministry of Health and Population
Mohamed, Mostafa
Egypt, Cairo
Egyptian Ministry of Health and Population
Wakeel, Aly El
Egypt, Faiyum
Ministry of Health and Population
Sayed, Mabrouk El
Egypt, Faiyum
Ministry of Health and Population
Hallaj, Zuhair S.
Switzerland, Geneva
Organisation Mondiale de la Santé
Curtale, Filippo
Italy, Rome
Osp. Spec. Mal. Infett.
Statistics
Citations: 11
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1007/s00436-007-0802-6
ISSN:
09320113
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Egypt