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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Bromocriptine treatment associated with recovery from peripartum cardiomyopathy in siblings: Two case reports
Journal of Medical Case Reports, Volume 4, Article 80, Year 2010
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Description
Introduction. Peripartum cardiomyopathy is a rare form of cardiomyopathy, with heterogeneous presentation occurring in women between one-month antepartum and six months postpartum. It carries a poor prognosis and a high risk of mortality. Case presentation. We report the development of peripartum cardiomyopathy in two sisters, 27-and 35-year-old African women, one of whom presented with a large left ventricular thrombus. Subsequently, both patients were treated with bromocriptine, heparin and standard therapy for heart failure (angiotensin converting enzyme inhibitors, beta-blockers and diuretics). During follow-up, the left ventricular thrombus observed in one patient degraded. Neither patient experienced a thrombotic event, and both experienced continuous improvements in cardiac function and New York Heart Association stage. Conclusion. The development of peripartum cardiomyopathy in two sisters indicates that there may be a genetic basis for this type of cardiomyopathy, and that women with a positive family history for peripartum cardiomyopathy may have an increased risk of developing the disease. This is also the first report of a patient experiencing degradation of a large left ventricular thrombus under standard therapy for heart failure with bromocriptine. It suggests that the use of bromocriptine in association with adequate anti-coagulation and heart failure therapy may be beneficial and safe. © 2010 Meyer et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Meyer, Gerd Peter
Germany, Hannover
Hannover Medical School
Labidi, Saida
Germany, Hannover
Hannover Medical School
Podewski, Edith Katharina
Germany, Hannover
Hannover Medical School
Sliwa, Karen S.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Drexler, Helmut
Germany, Hannover
Hannover Medical School
Hilfiker-Kleiner, Denise
Germany, Hannover
Hannover Medical School
Statistics
Citations: 36
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1186/1752-1947-4-80
ISSN:
17521947
e-ISSN:
17521947
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Female