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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Coronary artery in-stent stenosis persists despite inhibition of the von Willebrand factor - Collagen interaction in baboons
Thrombosis and Haemostasis, Volume 98, No. 6, Year 2007
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Description
Revascularization techniques, such as angioplasty and stent implantation, frequently lead to restenosis due to the formation of neointima after platelet activation and the concomittant release of various smooth muscle cell mitogenic and attractant factors. We here investigate whether inhibition of initial platelet adhesion after stent implantation can decrease neointima formation in a clinically relevant baboon model of in-stent stenosis using standard treatment with aspirin, clopidogrel and heparin. Inhibition of platelet adhesion was established by administration of the anti-von Willebrand factor (VWF) monoclonal antibody 82D6A3, which inhibits VWF binding to collagen. Administration of 82D6A3 resulted in a complete inhibition of VWF binding to collagen during the first three days after stent implantation. No thrombocytopenia or prolongation of the bleeding time was observed. Our results show that the formation of neointima was not affected in the group of baboons where primary platelet adhesion was abolished with 82D6A3 when compared to the control group. Vascular injury scores were the same in both groups. Inhibition of platelet adhesion during the first three days after stenting, on top of standard treatment with aspirin, clopidogrel and heparin, had no effect on neo-intima formation in a baboon model of in-stent stenosis. During the last decade, attempts to translate seemingly effective therapies based on smaller animal experimentation to the clinic have consistently failed. This study, using a non-human primate model that more closely resembles the clinical situation, presents a model that may be of further clinical interest for studying the prevention of restenosis. © 2007 Schattauer GmbH, Stuttgart.
Authors & Co-Authors
De Meyer, Simon F.
Belgium, Leuven
Ku Leuven
Staelens, Stephanie
Belgium, Leuven
Ku Leuven
Badenhorst, Philip Nel
South Africa, Bloemfontein
University of the Free State
Pieters, Henry
South Africa, Bloemfontein
University of the Free State
Lamprecht, Seb
South Africa, Bloemfontein
University of the Free State
Roodt, Jan P.
South Africa, Bloemfontein
University of the Free State
Janssens, Stefan P.
Belgium, Leuven
Ku Leuven
Meiring, Muriel S.
South Africa, Bloemfontein
University of the Free State
Vanhoorelbeke, Karen
Belgium, Leuven
Ku Leuven
Bruwer, A. D.B.
South Africa, Bloemfontein
University of the Free State
Brown, Stephen C.
South Africa, Bloemfontein
University of the Free State
Deckmyn, Hans
Belgium, Leuven
Ku Leuven
Statistics
Citations: 16
Authors: 12
Affiliations: 2
Identifiers
Doi:
10.1160/TH07-05-0335
ISSN:
03406245
Research Areas
Health System And Policy
Violence And Injury
Study Design
Randomised Control Trial