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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
I;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumors and cell lines
Genes, Chromosomes and Cancer, Volume 10, No. 2, Year 1994
Notification
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Description
We report on the finding of a t(1;17) in two primary neuroblastomas. Subsequent fluorescence in situ hybridization (FISH) analysis revealed the presence of 1; 17 transfocations in four out of nine neuroblastoma cell lines. The chromosome 1 short arm breakpoints were determined using region‐specific probes. FISH screening also demonstrated or confirmed the presence of 11;17 translocations in three cell lines and other chromosome 17 rearrangements in those cell lines that did not carry a t(1; 17) or t(11; 17). Our data extend previous cytogenetic findings and suggest that, in addition to the known involvement of chromosome I, one or more genes on chromosome 17 also play a role in neuroblastoma development. Genes Chromosom Cancer 10:103–114 (1994). © 1994 Wiley‐Liss, Inc. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Van Roy, Nadine
Belgium, Leuven
Rega Institute for Medical Research
Laureys, Geneviève
Belgium, Leuven
Rega Institute for Medical Research
Cheng, Ngan Ching
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Willem, P.
South Africa, Johannesburg
National Health Laboratory Service
Opedenakker, Ghislain
Belgium, Ghent
Universitair Ziekenhuis Gent
Belgium, Leuven
Rega Institute for Medical Research
Versteeg, Rogier
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Speleman, Frank
Belgium, Leuven
Rega Institute for Medical Research
Statistics
Citations: 133
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1002/gcc.2870100205
ISSN:
10452257
e-ISSN:
10982264
Research Areas
Cancer
Genetics And Genomics