Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Anti-inflammatory agents in the treatment of bipolar depression: A systematic review and meta-analysis
Bipolar Disorders, Volume 18, No. 2, Year 2016
Notification
URL copied to clipboard!
Description
Objective: Inflammation has been implicated in the risk, pathophysiology, and progression of mood disorders and, as such, has become a target of interest in the treatment of bipolar disorder (BD). Therefore, the objective of the current qualitative and quantitative review was to determine the overall antidepressant effect of adjunctive anti-inflammatory agents in the treatment of bipolar depression.Methods: Completed and ongoing clinical trials of anti-inflammatory agents for BD published prior to 15 May 15 2015 were identified through searching the PubMed, Embase, PsychINFO, and Clinicaltrials.gov databases. Data from randomized controlled trials (RCTs) assessing the antidepressant effect of adjunctive mechanistically diverse anti-inflammatory agents were pooled to determine standard mean differences (SMDs) compared with standard therapy alone.Results: Ten RCTs were identified for qualitative review. Eight RCTs (n = 312) assessing adjunctive nonsteroidal anti-inflammatory drugs (n = 53), omega-3 polyunsaturated fatty acids (n = 140), N-acetylcysteine (n = 76), and pioglitazone (n = 44) in the treatment of BD met the inclusion criteria for quantitative analysis. The overall effect size of adjunctive anti-inflammatory agents on depressive symptoms was -0.40 (95% confidence interval -0.14 to -0.65, p = 0.002), indicative of a moderate and statistically significant antidepressant effect. The heterogeneity of the pooled sample was low (I2 = 14%, p = 0.32). No manic/hypomanic induction or significant treatment-emergent adverse events were reported.Conclusions: Overall, a moderate antidepressant effect was observed for adjunctive anti-inflammatory agents compared with conventional therapy alone in the treatment of bipolar depression. The small number of studies, diversity of agents, and small sample sizes limited interpretation of the current analysis. Copyright © 2016 John Wiley & Sons A/S.
Authors & Co-Authors
Rosenblat, Joshua D.
Canada, Toronto
University of Toronto
Berk, Michael
Australia, Geelong
Deakin University
Australia, Melbourne
Orygen Youth Health
Vedel Kessing, Lars Vedel
Denmark, Copenhagen
Københavns Universitet
Baune, Bernhard T.
Australia, Adelaide
The University of Adelaide
Goldstein, Benjamin I.
Canada, Toronto
Sunnybrook Health Sciences Centre
Mcintyre, Roger S.
Canada, Toronto
University of Toronto
Statistics
Citations: 161
Authors: 6
Affiliations: 8
Identifiers
Doi:
10.1111/bdi.12373
ISSN:
13985647
Research Areas
Genetics And Genomics
Mental Health
Study Design
Randomised Control Trial
Study Approach
Qualitative
Quantitative
Systematic review