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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: A new repertoire evolves over 12 months
Vaccine, Volume 24, No. 14, Year 2006
Notification
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Description
Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this. The results of clonal analysis were compared to those obtained by skin testing and in a whole blood interferon gamma assay. Pre-vaccination antigen specific T-cell clones were detected, but the majority of clones present 12 months after vaccination were not present earlier. The magnitude of the clonal response did not correlate well with results of the other assays. These data indicate that single assays may not be reliable and that a stable memory T-cell repertoire is slow to develop. © 2005 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Bennett, Andrea R.
Unknown Affiliation
Gorak-Stolinska, Patricia M.A.
Unknown Affiliation
Ben-Smith, Anne W.
Unknown Affiliation
Floyd, Sian
Unknown Affiliation
de Lara, Catherine M.
Unknown Affiliation
Weir, Rosemary E.
Unknown Affiliation
Lalor, Maeve K.
Unknown Affiliation
Makamo, Kandakuone
Unknown Affiliation
Msiska, Glyn
Unknown Affiliation
Crampin, Amelia Catharine
Unknown Affiliation
Fine, Paul E.M.
Unknown Affiliation
Dockrell, Hazel M.
Unknown Affiliation
Beverley, Peter C.L.
Unknown Affiliation
Statistics
Citations: 13
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1016/j.vaccine.2005.12.011
ISSN:
0264410X
Study Locations
Malawi