Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Synthesis and biological evaluation of some novel thiazole compounds as potential anti-inflammatory agents
European Journal of Medicinal Chemistry, Volume 65, Year 2013
Notification
URL copied to clipboard!
Description
In the present investigation, furo[2,3-d]thiazol-5(2H)-one 5 was obtained from reaction of thiosemicarbazone derivative 2 with diethyl acetylene dicarboxylate. A series of newly synthesized 2-(hydrazinyl)thiazol-4(5H)-one 6, 7 & 8 and 2-(4-(substituted)-thiazol-2-yl)hydrazono derivatives 9a, b & 10 were synthesized from treatment of thiosemicarbazone derivative 2 with appropriate α-halogenated compounds. Also, a one pot synthesis of thiazole derivatives 13 & 15 was achieved from three components reaction of hydrazone derivative 11 with phenyl isothiocyanate and α-halogenated compounds catalyzed by DMF/KOH. 4-(4-Morpholino phenyl) thiazol-2-amino 17 was obtained via the reaction of acetophenone derivative 1 with thiourea in presence of iodine. The reactivity of 2-aminothiazole 17 toward some electrophilic reagents was investigated. The structure of the newly compounds was confirmed on the basis of elemental analysis and spectral data. The antibacterial activity towards two Gram negative (Proteus mirabilis & Serratia marcesens) and two Gram positive (Staphylococcus aureus & Bacillus cereus) bacteria was investigated. The anti-inflammatory activity was also investigated and the inhibition of the carrageenin-induced oedema by these compounds was established. © 2013 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Helal, Mohamed H.
Saudi Arabia, Arar
Northern Border University
Egypt, Cairo
Faculty of Science
Salem, Mohammed A.
Egypt, Cairo
Faculty of Science
Saudi Arabia, Abha
King Khalid University
Abd El-Aal El-Gaby, Mohamed S.
Saudi Arabia, Abha
King Khalid University
Egypt, Cairo
Faculty of Science
Aljahdali, Mutlaq Sh
Saudi Arabia, Arar
Northern Border University
Saudi Arabia, Jeddah
King Abdulaziz University
Statistics
Citations: 131
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejmech.2013.04.005
ISSN:
02235234
e-ISSN:
17683254