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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Evaluation of antileishmanial, cytotoxic and antioxidant activities of essential oils extracted from plants issued from the leishmaniasis-endemic region of Sned (Tunisia)
Natural Product Research, Volume 25, No. 12, Year 2011
Notification
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Description
In this study, we tested 10 essential oils (EOs) extracted from 10 plants issued from Sned region (Tunisia) to evaluate both their leishmanicidal effects against Leishmania major and L. infantum, and their cytotoxicity against murine macrophage cell line RAW 264.7 (ATCC, TIB-71). The antioxidant activity was also monitored by the DDPH method, while the chemical composition of active EO was assessed by GC-MS analysis. The results showed that the EOs obtained from Thymus hirtus sp. algeriensis (rich on monoterpenoids, especially linalool at 17.62% and camphor at 13.82%) is significantly active against both L. major and L. infantum, whereas Ruta chalepensis EO (rich on 2-undecanone at 84.28%) is only active against L. infantum. Both oil extracts showed low cytotoxicity towards murine macrophages. The characteristic ratios (IC 80 Raw264.7 cells/IC 50 L. infantum and IC 80 Raw264.7 cells/IC 50 L. major) were, respectively, 2.7 and 1.57 for T. hirtus sp. algeriensis, and 1.34 and 0.19 for R. chalepensis. However, when measuring the antioxidant effects (DDPH method), the two latter EOs presented a moderate 2,2-diphenyl-2-picrylhydrazyl hydrate scavenging effects compared to EOs from Eucaliptus globulus, Pinus halepensis, Pituranthos tortuosus, Rosmarinus officinalis, Tetraclinis articulata or to BHT. © 2011 Taylor & Francis.
Authors & Co-Authors
Ben Hadj Ahmed, Sami
Tunisia, Gafsa
Université de Gafsa
Sghaier, Rabiaa Manel
Tunisia, Tunis
Institut Pasteur de Tunis
Guesmi, Fatma
Tunisia, Gafsa
Université de Gafsa
Tunisia, Tunis
University of Carthage, Institut National Des Sciences Appliquées et de Technologie
Kâabi, Belhassen
Tunisia, Tunis
Institut Pasteur de Tunis
Mejri, Mondher
Tunisia, Moghrane
Institut Supérieur Des Etudes Technologiques de Zaghouan
Attia, Hanène
Tunisia, Tunis
Institut Pasteur de Tunis
Laouini, Dhafer
Tunisia, Tunis
Institut Pasteur de Tunis
Smaali, Issam
Tunisia, Tunis
University of Carthage, Institut National Des Sciences Appliquées et de Technologie
Statistics
Citations: 77
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1080/14786419.2010.534097
ISSN:
14786419
e-ISSN:
14786427
Study Locations
Tunisia