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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Identification of four novel KIR2DL2 alleles and two novel KIR2DL3 alleles in an East African population
Human Immunology, Volume 71, No. 12, Year 2010
Notification
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Description
We report four novel KIR2DL2 alleles and two novel KIR2DL3 alleles identified from an East African population using sequence-based typing. Sequencing and molecular cloning of exon 4 confirmed that the new 2DL2 alleles were identical to 2DL2*003, except for the following nucleotide differences: 2DL2*00601 had a difference at codon 16 (CGC→CCC), resulting in a coding change from arginine to proline; 2DL2*00602 also had this difference at codon 16, as well as a synonymous difference (GAT→GAC) at codon 31; 2DL2*00303 had a synonymous difference (AAA→AAG) at codon 61; and 2DL2*00304 had a synonymous difference (GGG→GGA) at codon 75. 2DL3*017 was identical to 2DL3*005 except at codon 11 (CGG→CTG, arginine→leucine) and exon 9, codons 297 (CAC→CGC, histidine→arginine) and 321 (TGA→AGA, stop codon→arginine). 2DL3*00104 was identical to KIR2DL3*001 except for a synonymous difference (GAG→GAA) at codon 54. Identification of novel killer cell immunoglobulin-like receptor (KIR) alleles is a testament to the genetic diversity in this population. © 2010 American Society for Histocompatibility and Immunogenetics.
Authors & Co-Authors
Hardie, R. A.
Canada, Winnipeg
University of Manitoba
Czarnecki, Chris
Canada, Ottawa
Public Health Agency of Canada
Ball, Terry Blake
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Plummer, Francis Allan
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Kenya, Nairobi
University of Nairobi
Luo, Ma
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Statistics
Citations: 9
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.humimm.2010.09.013
ISSN:
01988859
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study