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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lingonberry (Vaccinium vitis-idaea L.) exhibits antidiabetic activities in a mouse model of diet-induced obesity
Evidence-based Complementary and Alternative Medicine, Volume 2014, Article 645812, Year 2014
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Description
Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes. In a previous study, the ethanol extract of berries of V. vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK) pathway. The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes. C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids) for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO) were used. Treatment began by adding V. vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg) for a subsequent period of 8 weeks (total HFD, 16 weeks). The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model. This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle. V. vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways. The results of the present study confirm that V. vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies. © 2014 Hoda M. Eid et al.
Authors & Co-Authors
Eid, Hoda M.
Canada, Montreal
University of Montreal
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Canadian Institutes of Health Research
Egypt, Beni Suef
Beni-suef University
Ouchfoun, Meriem
Canada, Montreal
University of Montreal
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Canadian Institutes of Health Research
Brault, Antoine
Canada, Montreal
University of Montreal
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Canadian Institutes of Health Research
Vallerand, Diane
Canada, Montreal
University of Montreal
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Canadian Institutes of Health Research
Musallam, Lina
Canada, Montreal
University of Montreal
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Canadian Institutes of Health Research
Arnason, John Thor A.
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Canadian Institutes of Health Research
Haddad, Pierre Sélim
Canada, Montreal
University of Montreal
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Canadian Institutes of Health Research
Statistics
Citations: 7
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1155/2014/645812
ISSN:
1741427X
e-ISSN:
17414288
Research Areas
Noncommunicable Diseases