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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Immunohistochemical localization of CYP1A, vitellogenin and Zona radiata proteins in the liver of swordfish (Xiphias gladius L.) taken from the Mediterranean Sea, South Atlantic, South Western Indian and Central North Pacific Oceans
Aquatic Toxicology, Volume 71, No. 1, Year 2005
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Description
Cytochrome P4501A (CYP1A) monoxygenase, vitellogenin (Vtg) and Zona radiata proteins (Zrp) are frequently used as biomarkers of fish exposure to organic contaminants. In this work, swordfish liver sections obtained from the Mediterranean Sea, the South African coasts (South Atlantic and South Western Indian Oceans) and the Central North Pacific Ocean were immunostained with antisera against CYP1A, Zrp, and Vtg. CYP1A induction was found in hepatocytes, epithelium of the biliary ductus and the endothelium of large blood vessels of fish from the Mediterranean Sea and South African waters, but not from the Pacific Ocean. Zrp and Vtg were immunolocalized in hepatocytes of male swordfish from the Mediterranean Sea and from South African waters. Plasma Dot-Blot analysis, performed in Mediterranean and Pacific specimens, revealed the presence of Zrp and Vtg in males from Mediterranean but not from Pacific. These results confirm previous findings about the potential exposure of Mediterranean swordfish to endocrine, disrupting chemicals and raise questions concerning the possible presence of xenobiotic contaminants off the Southern coasts of South Africa in both the South Atlantic and South Western Indian Oceans. © 2004 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Desantis, Salvatore
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Corriero, Aldo
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Cirillo, Fedelia
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Deflorio, Michele
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Brill, Richard W.
United States, Silver Spring
Noaa National Marine Fisheries Service
Griffiths, M.
New Zealand, Wellington
Ministry of Fisheries
Lopata, Andreas Ludwig
South Africa, Cape Town
University of Cape Town
de la Serna, José Miguel
Spain, Fuengirola
Csic-ieo-coma - Centro Oceanográfico de Málaga
Bridges, Christopher Robert
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Kime, David E.
United Kingdom, Sheffield
The University of Sheffield
de Metrio, Gregorio D.
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Statistics
Citations: 37
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.aquatox.2004.10.005
ISSN:
0166445X
Study Locations
South Africa
Participants Gender
Male