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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Combined analysis of the prevalence of drug-resistant Hepatitis B virus in antiviral therapy-experienced patients in Europe (CAPRE)
Journal of Infectious Diseases, Volume 213, No. 1, Year 2016
Notification
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Description
Background European guidelines recommend treatment of chronic hepatitis B virus infection (CHB) with the nucleos(t)ide analogs (NAs) entecavir or tenofovir. However, many European CHB patients have been exposed to other NAs, which are associated with therapy failure and resistance. The CAPRE study was performed to gain insight in prevalence and characteristics of NA resistance in Europe. Methods A survey was performed on genotypic resistance testing results acquired during routine monitoring of CHB patients with detectable serum hepatitis B virus DNA in European tertiary referral centers. Results Data from 1568 patients were included. The majority (73.8%) were exposed to lamivudine monotherapy. Drug-resistant strains were detected in 52.7%. The most frequently encountered primary mutation was M204V/I (48.7%), followed by A181T/V (3.8%) and N236T (2.6%). In patients exposed to entecavir (n = 102), full resistance was present in 35.3%. Independent risk factors for resistance were age, viral load, and lamivudine exposure (P <. 001). Conclusions These findings support resistance testing in cases of apparent NA therapy failure. This survey highlights the impact of exposure to lamivudine and adefovir on development of drug resistance and cross-resistance. Continued use of these NAs needs to be reconsidered at a pan-European level. © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America.
Authors & Co-Authors
Hermans, Lucas Etienne
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Rotterdam
Erasmus Mc
Svicher, Valentina
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Pas, Suzan D.
Netherlands, Rotterdam
Erasmus Mc
Salpini, Romina
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Ben-Ari, Ziv
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Bruzzone, Bianca Marisa
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Coppola, N.
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Seguin-Devaux, Carole
Luxembourg, Strassen
Luxembourg Institute of Health
García, Federico Alcacer
Unknown Affiliation
Kaiser, Rolf
Germany, Koln
Universität zu Köln
Köse, Şükran
Unknown Affiliation
Krarup, Henrik B.
Denmark, Aalborg
Aalborg Universitetshospital
Lazarevic, Ivana B.
Serbia, Belgrade
University of Belgrade
Lunar, Maja M.
Slovenia, Ljubljana
Univerza V Ljubljani
Maylin, Sarah
France, Paris
Hôpital Saint-louis
Micheli, Valeria
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Mor, Orna
Israel, Jerusalem
Ministry of Health
Paraschiv, Simona
Romania, Bucharest
Matei Bals National Institute for Infectious Diseases
Paraskevis, D. N.
Greece, Athens
National and Kapodistrian University of Athens
Poljak, Mario
Slovenia, Ljubljana
Univerza V Ljubljani
Puchhammer-Stöckl, Elisabeth
Austria, Vienna
Medizinische Universität Wien
Simon, Franćois
France, Paris
Hôpital Saint-louis
Stanojevic, Maja
Serbia, Belgrade
University of Belgrade
Stene-Johansen, Kathrine
Norway, Oslo
Folkehelseinstituttet
Trimoulet, Pascale
France, Bordeaux
Université de Bordeaux
Verheyen, Jens
Germany, Duisburg
Universität Duisburg-essen
Vince, Adriana
Croatia, Zagreb
University of Zagreb School of Medicine
Weis, Nina M.
Denmark, Copenhagen
Copenhagen University Hospital
Zidovec Lepej, Snjezana
Croatia, Zagreb
University of Zagreb School of Medicine
Perno, Carlo Federico
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Boucher, Charles A.B.
Netherlands, Rotterdam
Erasmus Mc
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Statistics
Citations: 25
Authors: 32
Affiliations: 23
Identifiers
Doi:
10.1093/infdis/jiv363
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative