Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nebulized Hypertonic Saline in the Treatment of Viral Bronchiolitis in Infants
Journal of Pediatrics, Volume 151, No. 3, Year 2007
Notification
URL copied to clipboard!
Description
Objective: To investigate the use of nebulized 3% hypertonic saline (HS) for treating viral bronchiolitis in moderately ill hospitalized infants by a prospective, randomized, double-blinded, controlled, multicenter trial. Study design: A total of 96 infants (mean age, 4.7 months; range, 0.3 to 18 months) admitted to the hospital for treatment of viral bronchiolitis were recruited from 3 regional pediatric centers over 3 bronchiolitis seasons (December 2003 to May 2006). Patients were randomized to receive, in a double-blind fashion, repeated doses of nebulized 3% HS (treatment group) or 0.9% normal saline (NS; control group), in addition to routine therapy ordered by the attending physician. The principal outcome measure was hospital length of stay (LOS). Results: On an intention-to-treat basis, the infants in the HS group had a clinically relevant 26% reduction in LOS to 2.6 ± 1.9 days, compared with 3.5 ± 2.9 days in the NS group (P = .05). The treatment was well tolerated, with no adverse effects attributable to the use of HS. Conclusions: The use of nebulized 3% HS is a safe, inexpensive, and effective treatment for infants hospitalized with moderately severe viral bronchiolitis. © 2007 Mosby, Inc. All rights reserved.
Authors & Co-Authors
Kuzik, Brian A.
United Arab Emirates, Abu Dhabi
Sheikh Khalifa Medical City
Al Qadhi, Samim A.
United Arab Emirates, Abu Dhabi
Sheikh Khalifa Medical City
Kent, Steven
Canada, Vancouver
The University of British Columbia
Flavin, Michael P.
Canada, Kingston
Queen’s University
Hopman, Wilma M.
Canada, Kingston
Kingston General Hospital, Ontario
Hotte, Simon
Canada, Kingston
Queen’s University
Gander, Sarah
Canada, Kingston
Queen’s University
Statistics
Citations: 152
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.jpeds.2007.04.010
ISSN:
00223476
Research Areas
Disability
Health System And Policy
Study Design
Randomised Control Trial
Cohort Study