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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis
Blood, Volume 119, No. 14, Year 2012
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Description
Immune reconstitution inflammatory syndrome (IRIS) is a common and potentially serious complication occurring in HIV-infected patients being treated for tuberculosis (TB) using combined antiretroviral treatment. A role of adaptive immunity has been suggested in the onset of IRIS, whereas the role of natural killer (NK) cells has not yet been explored. The present study sought to examine the involvement of NK cells in the onset of IRIS in HIV-infected patients with TB and to identify predictive markers of IRIS. A total of 128 HIV-infected patients with TB from the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) trial were enrolled in Cambodia. Thirty-seven of the 128 patients developed IRIS. At inclusion, patients had low CD4 cell counts (27 cells/mm3) and high plasma viral load (5.76 and 5.50 log/mL in IRIS and non-IRIS patients, respectively). At baseline, NK-cell degranulation capacity was significantly higher in IRIS patients than in non-IRIS patients (9.6% vs 6.38%, P < .005). At IRIS onset, degranulation capacity did not differ between patients, whereas activating receptor expression was lower in IRIS patients. Patients with degranulation levels > 10.84% had a higher risk of IRIS (P = .002 by log-rank test). Degranulation level at baseline was the most important IRIS predictor (hazard ratio = 4.41; 95% confidence interval, 1.60-12.16). We conclude that NK-degranulation levels identify higher IRIS risk in HIV-infected patients with TB. © 2012 by The American Society of Hematology.
Authors & Co-Authors
Pean, Polidy
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Nerrienet, Eric
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Madec, Yoann
France, Paris
Institut Pasteur, Paris
Borand, Laurence
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Laureillard, Didier
Cambodia, Phnom Penh
Cambodian Health Committee
Marcy, Olivier
Cambodia, Phnom Penh
Cambodian Health Committee
Taylor, Sylvia M.
France, Paris
Institut Pasteur, Paris
Pancino, Gianfranco
France, Paris
Institut Pasteur, Paris
Barré-Sinoussi, Françoise C.
France, Paris
Institut Pasteur, Paris
Scott-Algara, Daniel
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 60
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1182/blood-2011-09-377523
ISSN:
00064971
Research Areas
Environmental
Infectious Diseases