Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Chronic hepatitis B and C virus infection and risk for non-hodgkin lymphoma in HIV-infected patients: A cohort study
Annals of Internal Medicine, Volume 166, No. 1, Year 2017
Notification
URL copied to clipboard!
Description
Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIVinfected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). Patients: HIV-infected patients with information on HBV surface antigen measurements and detectable HCV RNA, or a positive HCV antibody test result if HCV RNA measurements were not available. Measurements: Time-dependent Cox models to assess risk for NHL in treatment-naive patients and those initiating ART, with inverse probability weighting to control for informative censoring. Results: A total of 52 479 treatment-naive patients (1339 [2.6%] with chronic HBV infection and 7506 [14.3%] with HCV infection) were included, of whom 40 219 (77%) later started ART. The median follow-up was 13 months for treatment-naive patients and 50 months for those receiving ART. A total of 252 treatmentnaive patients and 310 treated patients developed NHL, with incidence rates of 219 and 168 cases per 100 000 person-years, respectively. The hazard ratios for NHL with HBV and HCV infection were 1.33 (95% CI, 0.69 to 2.56) and 0.67 (CI, 0.40 to 1.12), respectively, in treatment-naive patients and 1.74 (CI, 1.08 to 2.82) and 1.73 (CI, 1.21 to 2.46), respectively, in treated patients. Limitation: Many treatment-naive patients later initiated ART, which limited the study of the associations of chronic HBV and HCV infection with NHL in this patient group. Conclusion: In HIV-infected patients receiving ART, chronic coinfection with HBV and HCV is associated with an increased risk for NHL. © 2017 American College of Physicians.
Authors & Co-Authors
De Luca, Andrea
Italy, Siena
Azienda Ospedaliera Universitaria Senese
Smith, Colette Joanne
United Kingdom, London
University College London
Zangerle, Robert
Austria, Innsbruck
Medizinische Universitat Innsbruck
Bonnet, Fabrice
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Smit, Colette
Netherlands, Amsterdam
Stichting Hiv Monitoring
Thornton, Alicia Claire
United Kingdom, London
University College London
Berenguer, Juan J.
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Peters, Lars
Denmark, Copenhagen
Rigshospitalet
Spagnuolo, Vincenzo
Italy, Milan
Irccs Ospedale San Raffaele
Ammassari, Adriana
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Antinori, Andrea
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Quiròs-Roldan, Eugenia
Italy, Brescia
Università Degli Studi Di Brescia
Mussini, Cristina
Italy, Modena
Azienda Ospedaliero - Universitaria Di Modena
Italy, Modena
Modena Cohort
Miró, José María
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Konopnicki, Deborah
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Fehr, Jan Sven
Switzerland, Zurich
Universität Zürich
Campbell, Maria Athena
Denmark, Herlev
Steno Diabetes Center Copenhagen
Termote, Monique
France, Bordeaux
Université de Bordeaux
Bucher, Heíner C.C.
Switzerland, Basel
Universitätsspital Basel
de Wit, Stéphane A.
Unknown Affiliation
Costagliola, Dominique G.
France
Fhdh
D'Arminio Monforte, Antonella D.
Unknown Affiliation
Castagna, Antonella
Unknown Affiliation
del Amo, Julia
Unknown Affiliation
Mocroft, Amanda J.
Unknown Affiliation
Raben, Dorthe
Unknown Affiliation
Chêne, Geneviève
France, Bordeaux
Bordeaux Regional Coordinating Centre
Touloumi, Giota
United States, New York
Amacs
Warszawski, Josiane
Unknown Affiliation
Meyer, Laurence J.
France
Anrs Co2 Seroco
Dabis, Franćois Ç.Ois
France
Anrs Co3 Aquitaine
Krause, Murielle Mary
France
Anrs Co4 Fhdh
Ghosn, Jade
France
Anrs Co6 Primo
Leport, Catherine
France
Anrs Co8 Copilote
Wittkop, Linda
France
Anrs Co13 Hepavih
Reiss, Peter
Unknown Affiliation
Wit, Ferdinand W.N.M.
Unknown Affiliation
Prins, Maria
Unknown Affiliation
Sabin, Caroline Anne
Unknown Affiliation
Gibb, Diana M.
Unknown Affiliation
Fätkenheuer, Gerd
Unknown Affiliation
Obel, Niels
Denmark
Danish Hiv Cohort
Thorne, Claire N.
Unknown Affiliation
Kirk, Ole
Unknown Affiliation
Stephan, Christoph J.
Unknown Affiliation
Pérez-Hoyos, Santiago
Unknown Affiliation
Hamouda, Osamah
Germany
German Clinsurv
Gunsenheimer-Bartmeyer, Barbara
Germany
German Clinsurv
Chkhartishvili, Nikoloz I.
United States
Georgian National Hiv/aids
Noguera-Julián, Antoni Diez
Unknown Affiliation
Brockmeyer, Norbert Hermann
Poland
Kompnet
Prieto, Luis Alberto
Spain, Madrid
Madrid Pmtct Cohort
Conejo, Pablo Rojo
Spain, Madrid
Corispes-madrid
Soriano-Arandes, Antoni
Spain
Nenexp
Battegay, Manuel
Unknown Affiliation
Rauch, Andri
Unknown Affiliation
Tookey, Pat A.
United Kingdom
Nshpc
Casabona, Jordi
Unknown Affiliation
Goetghebuer, Tessa
Unknown Affiliation
Sönnerborg, Anders B.
Sweden
Swedish Infcare
Torti, Carlo
Italy
Italian Master Cohort
Teira, Ramón M.
Unknown Affiliation
Garrido, Myriam
Unknown Affiliation
Haerry, David Hans Ulrich
Belgium, Brussels
European Aids Treatment Group
Bohlius, Julia
Unknown Affiliation
Bouteloup, Vincent
Unknown Affiliation
Cozzi-Lepri, Alessandro
Unknown Affiliation
Davies, M. A.
Unknown Affiliation
Dorrucci, Maria
Unknown Affiliation
Dunn, David T.
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Furrer, Hansjakob
Unknown Affiliation
Guiguet, Marguerite
Unknown Affiliation
Grabar, Sophie G.
Unknown Affiliation
Judd, Ali M.
Unknown Affiliation
Lambotte, Olivier
Unknown Affiliation
Leroy, Valeriane
Unknown Affiliation
Lodi, Sara
Unknown Affiliation
Matheron, Sophie
Unknown Affiliation
Monge, Susana
Unknown Affiliation
Nakagawa, Fumiyo
Unknown Affiliation
Paredes, Roger
Unknown Affiliation
Phillips, Andrew N.
Unknown Affiliation
Puoti, Massimo
Unknown Affiliation
Schomaker, Michael
Unknown Affiliation
Sterne, Jonathan A.C.
Unknown Affiliation
Thíébaut, Rodolphe
Unknown Affiliation
van der Valk, Marc
Unknown Affiliation
Wyss, Natasha
Unknown Affiliation
Barger, Diana
Unknown Affiliation
Schwimmer, Christine
Unknown Affiliation
Friis-Möller, Nina
Unknown Affiliation
Kjaer, Jesper
Unknown Affiliation
Brandt, Rikke Salbøl
Unknown Affiliation
Statistics
Citations: 38
Authors: 94
Affiliations: 40
Identifiers
Doi:
10.7326/M16-0240
ISSN:
00034819
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative