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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis
Journal of Infectious Diseases, Volume 205, No. 1, Year 2012
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Description
Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis patients. Mortality (54%) was associated with higher CSF EBV load when adjusted for HIV (P =. 01). CMV was detected in 11 of 115 HIV-infected patients, 8 of whom died. The mechanisms by which EBV and CMV contribute to poor outcome require further investigation. © 2011 The Author.
Authors & Co-Authors
Kelly, Matthew J.
United Kingdom, Liverpool
University of Liverpool
Benjamin, Laura A.
United Kingdom, Liverpool
University of Liverpool
Cartwright, Katharine E.
Malawi, Zomba
University of Malawi
United Kingdom, Leicester
Leicester Royal Infirmary
Ajdukiewicz, Katherine M.A.
Malawi, Zomba
University of Malawi
United Kingdom, Manchester
North Manchester General Hospital
Cohen, Daniëlle
Malawi, Zomba
University of Malawi
United Kingdom, Sheffield
Sheffield Teaching Hospitals Nhs Foundation Trust
Menyere, Mavis
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Galbraith, Sareen E.
United Kingdom, Liverpool
University of Liverpool
Guiver, Malcolm
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
Neuhann, H. Florian
Germany, Heidelberg
Universitätsklinikum Heidelberg
Solomon, Tom
United Kingdom, Liverpool
University of Liverpool
Lalloo, David G.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Heyderman, Robert Simon
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Statistics
Citations: 48
Authors: 12
Affiliations: 9
Identifiers
Doi:
10.1093/infdis/jir707
ISSN:
00221899
Research Areas
Infectious Diseases