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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV-1 subtype C in vitro growth and coreceptor utilization
Virology, Volume 347, No. 2, Year 2006
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Description
Human immunodeficiency virus type 1 subtype C (HIV-1C) accounts for about 50% of all HIV infections in the pandemic and is the predominant subtype in the heavily burdened region of southern Africa. HIV-1C possesses unique genetic and phenotypic features that might be associated with biological differences compared to other subtypes. Here, we generated virus isolates from individuals at different stages of HIV-1C infection and investigated the chemokine receptor repertoire that the derived HIV-1C isolates may utilize for entry. Our results show that the R5 phenotype predominates among viruses in Botswana, with a lesser contribution of viruses showing the dualtropic X4R5 phenotype. No viruses of pure X4 phenotype were found, which suggests no discernable evolution of HIV-1C to a monotropic X4 phenotype as the epidemic ages in Botswana. Usage of other coreceptors was rare and apparently insignificant. These results enhance our understanding of HIV-1C biology, with implications for designing and testing therapeutic and prophylactic agents. © 2005 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Ndung'u, Thumbi P.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Sepako, Enoch
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
McLane, Mary Fran
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Chand, Fatima
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Bedi, Keabetswe
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Gaseitsiwe, Simani
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Doualla-Bell, Florence
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Canada, Montreal
Institut Lady Davis de Recherches Médicales
Peter, Trevor F.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Thior, Ibou
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Moyo, Sikhulile M.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Gilbert, Peter B.
United States, Seattle
University of Washington
Novitsky, Vladimir A.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Essex, Max E.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Statistics
Citations: 49
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1016/j.virol.2005.11.047
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Botswana