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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A2BAR signaling in intestinal epithelial cells
Cell Reports, Volume 40, No. 5, Article 111150, Year 2022
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Description
Intestinal nematode parasites can cross the epithelial barrier, causing tissue damage and release of danger-associated molecular patterns (DAMPs) that may promote host protective type 2 immunity. We investigate whether adenosine binding to the A2B adenosine receptor (A2BAR) on intestinal epithelial cells (IECs) plays an important role. Specific blockade of IEC A2BAR inhibits the host protective memory response to the enteric helminth, Heligmosomoides polygyrus bakeri (Hpb), including disruption of granuloma development at the host-parasite interface. Memory T cell development is blocked during the primary response, and transcriptional analyses reveal profound impairment of IEC activation. Extracellular ATP is visualized 24 h after inoculation and is shown in CD39-deficient mice to be critical for the adenosine production mediating the initiation of type 2 immunity. Our studies indicate a potent adenosine-mediated IEC pathway that, along with the tuft cell circuit, is critical for the activation of type 2 immunity. © 2022 The Authors
Authors & Co-Authors
Chen, Fei
United States, Newark
Rutgers new Jersey Medical School
United States, Newark
Rutgers University-newark
Robson, Simon Christopher
United States, Boston
Beth Israel Deaconess Medical Center
Di Virgilio, Francesco
Italy, Ferrara
University of Ferrara
Edelblum, Karen L.
United States, Newark
Rutgers new Jersey Medical School
United States, Newark
Rutgers University-newark
Statistics
Citations: 9
Authors: 4
Affiliations: 6
Identifiers
Doi:
10.1016/j.celrep.2022.111150
ISSN:
22111247