Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors
Tetrahedron Letters, Volume 51, No. 48, Year 2010
Notification
URL copied to clipboard!
Description
3-(Chloromethyl)coumarins, obtained via acid-catalysed cyclisation of salicylaldehyde-derived Baylis-Hillman adducts, have been treated with propargylamine; reaction of the resulting 3-alkynylmethylcoumarins with azidothymidine (AZT) in the presence of a Cu(I) catalyst has afforded a series of cycloaddition products for evaluation, in their own right, as potential dual-action HIV-1 protease and non-nucleoside reverse transcriptase inhibitors, and as scaffolds for further structural elaboration. © 2010 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Olomola, Temitope O.
South Africa, Grahamstown
Rhodes University
Klein, Rosalyn
South Africa, Grahamstown
Rhodes University
Lobb, Kevin A.
South Africa, Grahamstown
Rhodes University
Sayed, Yasien
South Africa, Johannesburg
University of the Witwatersrand
Kaye, Perry T.
South Africa, Grahamstown
Rhodes University
Statistics
Citations: 51
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.tetlet.2010.09.121
ISSN:
00404039
Research Areas
Infectious Diseases