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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Interleukin-8 Release in Baboon Septicemia Is Partially Dependent on Tumor Necrosis Factor
Journal of Infectious Diseases, Volume 167, No. 6, Year 1993
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Description
The role of tumor necrosis factor (TNF) in interleukin (IL)-8 release in septicemia in the baboon (2-h infusion of live Escherichia coli 5 × 108 cfu/kg) was investigated. Four experiments were done: one control (n = 7) and three with pretreatment to reduce TNF plasma levels. Pretreatment was with anti-TNF antibody (anti-TNF) 15 rug/kg, which neutralized circulating TNF (n = 4); 0.5 rug/kg of anti-TNF, which reduced peak TNF from 6.2 ng/ml, (controls) to 0.6 ng/ml, (n = 4); and a xanthine derivate (HWA138), which reduced TNF to 1 ng/mL (n = 5). With TNF levels < 1 ng/ml., a significant reduction of circulating IL-8 from 10.4 ng/mL (peak) in controls to 1 ng/mL (peak) in anti-TNF-treated animals was found, but with HWA138 only some decrease in IL-8 was seen. Despite high endotoxin levels (10-30 ng/mL peak), neutralization of TNF resulted in diminished release of IL-8 and significantly lower levels of granulocyte elastase. © 1993 by The University of Chicago.
Authors & Co-Authors
Redl, Heinz
Austria, Vienna
Ludwig Boltzmann Institut Für Experimentelle Und Klinische Traumatologie
Schlag, Günther
Austria, Vienna
Ludwig Boltzmann Institut Für Experimentelle Und Klinische Traumatologie
Ceska, Miroslav
Austria, Vienna
Ludwig Boltzmann Institut Für Experimentelle Und Klinische Traumatologie
Davies, James
Austria, Vienna
Ludwig Boltzmann Institut Für Experimentelle Und Klinische Traumatologie
Buurman, Wim A.
Austria, Vienna
Ludwig Boltzmann Institut Für Experimentelle Und Klinische Traumatologie
South Africa
Roodeplaat Research Laboratories
Netherlands, Maastricht
Universiteit Maastricht
Redl, Heinz
South Africa
Roodeplaat Research Laboratories
Netherlands, Maastricht
Universiteit Maastricht
Schlag, Gunther
South Africa
Roodeplaat Research Laboratories
Netherlands, Maastricht
Universiteit Maastricht
Ceska, Miroslav
South Africa
Roodeplaat Research Laboratories
Netherlands, Maastricht
Universiteit Maastricht
Davies, James
South Africa
Roodeplaat Research Laboratories
Netherlands, Maastricht
Universiteit Maastricht
Statistics
Citations: 40
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/167.6.1464
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Cancer