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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
CTLA-4 Exon 1 (+49) and Promoter (-318) Gene Polymorphisms in Kidney Transplantation
Transplantation Proceedings, Volume 38, No. 7, Year 2006
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Description
To investigate the association between kidney transplant rejection and the polymorphisms of CTLA-4 gene exon 1(+49) and promoter (-318), genomic DNA of 70 renal transplant recipients and 110 healthy blood donors were genotyped by PCR-RFLP and PCR-SSP, respectively. The patients were classified in two groups: G1 included 33 HLA-identical recipients and G2, 37 one haplo-identical recipients. Thirty-one recipients experienced an acute rejection episode: 10 in G1 and 21 in G2. Ten G2 patients developed chronic allograft dysfunction (CAD). Allelic frequencies and genotype distribution were similar among patients and controls. CTLA-4 exon 1 genotype A/A and CTLA-4 promoter genotype C/C were significantly higher among G2 patients with CAD than without CAD (P < .01). The distribution of CTLA-4 exon 1-promoter genes did not reach significance between graft recipients and controls. The genotype frequency of (G/G-C/C) was increased among controls (42.72%) compared with graft recipients (G1 and G2; 35.71%). CTLA-4 polymorphisms gene were associated with susceptibility to chronic allograft dysfunction. © 2006 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Gorgi, Yousr Lakhoua
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Sfar, Imen
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Ben Abdallah, Taïeb
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Abderrahim, Ezzedine
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Ayed, Saloua Jendoubi
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Aouadi, Houda
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Bardi, Rafika
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Ayed, Khaled
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Statistics
Citations: 31
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1016/j.transproceed.2006.06.132
ISSN:
00411345
Research Areas
Genetics And Genomics